Anti-cancer effects of Polyphyllin I: An update in 5 years
Y Tian, GY Gong, LL Ma, ZQ Wang, D Song… - Chemico-Biological …, 2020 - Elsevier
Chong-lou, the rhizome of Paris polyphylla, has been used in herbal regimes to treat
parotitis, mastitis and certain malignant tumors for thousands of years in traditional medicine …
parotitis, mastitis and certain malignant tumors for thousands of years in traditional medicine …
The interconnections between autophagy and integrin-mediated cell adhesion
A Vlahakis, J Debnath - Journal of molecular biology, 2017 - Elsevier
Autophagy is a cellular degradation process integral for promoting cellular adaptation during
metabolic stress while also functioning as a cellular homeostatic mechanism. Mounting …
metabolic stress while also functioning as a cellular homeostatic mechanism. Mounting …
The IAP family member BRUCE regulates autophagosome–lysosome fusion
P Ebner, I Poetsch, L Deszcz, T Hoffmann… - Nature …, 2018 - nature.com
Autophagy has an important role in cellular homeostasis by degrading and recycling
cytotoxic components. Ubiquitination is known to target cargoes for autophagy; however, key …
cytotoxic components. Ubiquitination is known to target cargoes for autophagy; however, key …
[HTML][HTML] Cardioprotective effect of MLN4924 on ameliorating autophagic flux impairment in myocardial ischemia-reperfusion injury by Sirt1
J Zhang, J Cui, F Zhao, L Yang, X Xu, Y Shi, B Wei - Redox Biology, 2021 - Elsevier
Neddylation is essential for cardiomyocyte survival in the presence of oxidative stress, and it
participates in autophagy regulation. However, whether MLN4924—an inhibitor of …
participates in autophagy regulation. However, whether MLN4924—an inhibitor of …
Functional analysis of Cullin 3 E3 ligases in tumorigenesis
Abstract Cullin 3-RING ligases (CRL3) play pivotal roles in the regulation of various
physiological and pathological processes, including neoplastic events. The substrate …
physiological and pathological processes, including neoplastic events. The substrate …
Targeting apoptosis dysregulation in myeloid malignancies-The promise of a therapeutic revolution
In recent years, the therapeutic landscape of myeloid malignancies has been completely
revolutionized by the introduction of several new drugs, targeting molecular alterations or …
revolutionized by the introduction of several new drugs, targeting molecular alterations or …
TAS4464, a highly potent and selective inhibitor of NEDD8-activating enzyme, suppresses neddylation and shows antitumor activity in diverse cancer models
C Yoshimura, H Muraoka, H Ochiiwa, S Tsuji… - Molecular Cancer …, 2019 - AACR
Abstract NEDD8-activating enzyme (NAE) is an essential E1 enzyme of the NEDD8
conjugation (neddylation) pathway, which controls cancer cell growth and survival through …
conjugation (neddylation) pathway, which controls cancer cell growth and survival through …
The emerging role for Cullin 4 family of E3 ligases in tumorigenesis
As a member of the Cullin-RING ligase family, Cullin-RING ligase 4 (CRL4) has drawn much
attention due to its broad regulatory roles under physiological and pathological conditions …
attention due to its broad regulatory roles under physiological and pathological conditions …
Small molecule inhibitors for hepatocellular carcinoma: advances and challenges
MA Kamal, YM Mandour, MK Abd El-Aziz, U Stein… - Molecules, 2022 - mdpi.com
Highlights: Multi tyrosine kinase inhibitors licensed for HCC treatment. Multi kinase inhibitors
not licensed for HCC treatment. Inhibitors of Growth Factor Receptors. Small molecules …
not licensed for HCC treatment. Inhibitors of Growth Factor Receptors. Small molecules …
Gigaxonin E3 ligase governs ATG16L1 turnover to control autophagosome production
Autophagy is an essential self-digestion machinery for cell survival and homoeostasis.
Membrane elongation is fundamental, as it drives the formation of the double-membrane …
Membrane elongation is fundamental, as it drives the formation of the double-membrane …