[HTML][HTML] Multitissue H3K27ac profiling of GTEx samples links epigenomic variation to disease

L Hou, X Xiong, Y Park, C Boix, B James, N Sun, L He… - Nature Genetics, 2023 - nature.com
Genetic variants associated with complex traits are primarily noncoding, and their effects on
gene-regulatory activity remain largely uncharacterized. To address this, we profile …

[HTML][HTML] Genetic evidence for causal effects of immune dysfunction in psychiatric disorders: where are we?

O Iakunchykova, EH Leonardsen, Y Wang - Translational Psychiatry, 2024 - nature.com
The question of whether immune dysfunction contributes to risk of psychiatric disorders has
long been a subject of interest. To assert this hypothesis a plethora of correlative evidence …

[HTML][HTML] Microglia and other cellular mediators of immunological dysfunction in schizophrenia: a narrative synthesis of clinical findings

KD Nguyen, A Amerio, A Aguglia, L Magnani, A Parise… - Cells, 2023 - mdpi.com
Schizophrenia is a complex psychiatric condition that may involve immune system
dysregulation. Since most putative disease mechanisms in schizophrenia have been …

[HTML][HTML] Whole-genome sequencing analysis of suicide deaths integrating brain-regulatory eQTLs data to identify risk loci and genes

S Han, E DiBlasi, ET Monson, A Shabalin, E Ferris… - Molecular …, 2023 - nature.com
Recent large-scale genome-wide association studies (GWAS) have started to identify
potential genetic risk loci associated with risk of suicide; however, a large portion of suicide …

Mental personality disorders: Current state of the problem statement

L Spytska - Kyiv journal of modern psychology and psychotherapy, 2023 - mpp-journal.com
The stages of personality formation are regulated by qualitative and quantitative changes in
a person's physiological development and the consequences of his interaction with the …

ПСИХІЧНІ РОЗЛАДИ ОСОБИСТОСТІ: СУЧАСНИЙ СТАН ПОСТАНОВКИ ПРОБЛЕМИ

Л Спицька - «Наукові записки Національного університету « …, 2023 - journals.oa.edu.ua
Анотація Метою науково-дослідної роботи було визначення особливостей зовнішніх
рушійних чинників, що призводять до розвитку деструктивних новоутворень у психічній …

An Integrated General Theory of Psychopathology and Suicide

CA Soper - Evolutionary Psychological Science, 2023 - Springer
This article presents biological meta-theory that is intended to serve as a shared key to
progress in psychiatry and suicidology. It argues that diverse forms of psychopathology …

A statistical method for image-mediated association studies discovers genes and pathways associated with four brain disorders

J He, L Antonyan, H Zhu, K Ardila, Q Li… - The American Journal of …, 2024 - cell.com
Brain imaging and genomics are critical tools enabling characterization of the genetic basis
of brain disorders. However, imaging large cohorts is expensive and may be unavailable for …

Gene expression profiling of monocytes in recent-onset schizophrenia

R Kübler, PR Ormel, IEC Sommer, RS Kahn… - Brain, Behavior, and …, 2023 - Elsevier
Immune–related mechanisms have been suggested to be involved in schizophrenia.
Various studies have shown changes in monocytes isolated from the blood of schizophrenia …

[HTML][HTML] Anti-Spike Antibody Responses to SARS-CoV-2 mRNA Vaccines in People with Schizophrenia and Schizoaffective Disorder

K Nemani, L De Picker, F Dickerson, M Leboyer… - Brain, Behavior, & …, 2024 - Elsevier
Importance Individuals with schizophrenia are at higher risk for severe COVID-19 illness and
severe breakthrough infection following vaccination. It is unclear whether immune response …