[HTML][HTML] Cholesterol-induced toxicity: An integrated view of the role of cholesterol in multiple diseases

Y Song, J Liu, K Zhao, L Gao, J Zhao - Cell metabolism, 2021 - cell.com
High levels of cholesterol are generally considered to be associated with atherosclerosis. In
the past two decades, however, a number of studies have shown that excess cholesterol …

Cholesterol-rich lipid rafts as platforms for SARS-CoV-2 entry

SN Palacios-Rápalo, LA De Jesus-Gonzalez… - Frontiers in …, 2021 - frontiersin.org
Since its appearance, the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2),
the causal agent of Coronavirus Disease 2019 (COVID-19), represents a global problem for …

How can we use the endocytosis pathways to design nanoparticle drug-delivery vehicles to target cancer cells over healthy cells?

VT Cong, JL Houng, M Kavallaris, X Chen… - Chemical Society …, 2022 - pubs.rsc.org
Targeted drug delivery in cancer typically focuses on maximising the endocytosis of drugs
into the diseased cells. However, there has been less focus on exploiting the differences in …

COVID-19: immunohistochemical analysis of TGF-β signaling pathways in pulmonary fibrosis

CB Vaz de Paula, S Nagashima, V Liberalesso… - International journal of …, 2021 - mdpi.com
Acute respiratory distress syndrome (ARDS) followed by repair with lung remodeling is
observed in COVID-19. These findings can lead to pulmonary terminal fibrosis, a form of …

Modulation of macrophage immunometabolism: A new approach to fight infections

T Gauthier, W Chen - Frontiers in Immunology, 2022 - frontiersin.org
Macrophages are essential innate immune cells that contribute to host defense during
infection. An important feature of macrophages is their ability to respond to extracellular cues …

Coronavirus infection and cholesterol metabolism

J Dai, H Wang, Y Liao, L Tan, Y Sun, C Song… - Frontiers in …, 2022 - frontiersin.org
Host cholesterol metabolism remodeling is significantly associated with the spread of human
pathogenic coronaviruses, suggesting virus-host relationships could be affected by …

Metabolic alterations upon SARS-CoV-2 infection and potential therapeutic targets against coronavirus infection

P Chen, M Wu, Y He, B Jiang, ML He - Signal Transduction and …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) caused by coronavirus SARS-CoV-2
infection has become a global pandemic due to the high viral transmissibility and …

Simvastatin downregulates the SARS-CoV-2-induced inflammatory response and impairs viral infection through disruption of lipid rafts

L Teixeira, JR Temerozo, FS Pereira-Dutra… - Frontiers in …, 2022 - frontiersin.org
Coronavirus disease 2019 (COVID-19) is currently a worldwide emergency caused by
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). In observational clinical …

Interaction of SARS-CoV-2 with host cells and antibodies: experiment and simulation

H Nguyen, HL Nguyen, PD Lan, NQ Thai… - Chemical Society …, 2023 - pubs.rsc.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
the devastating global COVID-19 pandemic announced by WHO in March 2020. Through …

Role of lipid rafts in pathogen-host interaction-a mini review

R Kulkarni, EAC Wiemer, W Chang - Frontiers in Immunology, 2022 - frontiersin.org
Lipid rafts, also known as microdomains, are important components of cell membranes and
are enriched in cholesterol, glycophospholipids and receptors. They are involved in various …