Noncovalent interactions are essential for the existence of solid and liquid phases. 1, 2
Traditionally touted as weak forces, quantification of these interactions, which govern the …

RNA therapeutics (eg siRNA, oligonucleotides, mRNA, etc.) show great potential for the
treatment of a myriad of diseases. However, to reach their site of action in the cytosol or …

To deliver siRNA for therapeutic use, several hurdles must be addressed. Metabolic
degradation must be blocked, and the RNAi cellular machinery is located in the cytoplasm …

Platelets are blood cells with numerous crucial pathophysiological roles in hemostasis,
cardiovascular thrombotic events and cancer metastasis. Platelet activation requires the …

One of the major obstacles to the pharmaceutical success of oligonucleotide therapeutics
(ONTs) is efficient delivery from the point of injection to the intracellular setting where …

Drug discovery strategies have advanced significantly towards prioritizing target selectivity
to achieve the longstanding goal of identifying “magic bullets” amongst thousands of …

A wider application of si RNA‐and mi RNA‐based therapeutics is restricted by the currently
available delivery systems. We have designed a new type of small molecule carrier (SM o C) …

The discovery of novel biologically active small molecules is now a technologically and
economically viable proposition for academic and small biotechnology laboratories wishing …

Cation–\uppi π or cation–2\uppi π interactions generally exist between one cation and one
or two electron-rich\uppi π-ring, which play an important role in many areas (such as …

Stem cell technology is an invaluable tool in tissue engineering and regenerative medicine,
with induced pluripotent stem cells (iPSCs) providing the means to design: autologous cell …