Status of reactive non-heme metal–oxygen intermediates in chemical and enzymatic reactions
Selective functionalization of unactivated C–H bonds, water oxidation, and dioxygen
reduction are extremely important reactions in the context of finding energy carriers and …
reduction are extremely important reactions in the context of finding energy carriers and …
C H Bond Activation in Transition Metal Species from a Computational Perspective
Alkanes constitute the cheapest and most abundant feedstock for organic chemicals.
However, the redistribution of CsC and CsH bonds in hydrocarbons into more sophisticated …
However, the redistribution of CsC and CsH bonds in hydrocarbons into more sophisticated …
Hybrid molecules with a dual mode of action: dream or reality?
B Meunier - Accounts of chemical research, 2008 - ACS Publications
The drug market is still dominated by small molecules, and more than 80% of the clinical
development of drug candidates in the top 20 pharmaceutical firms is still based on small …
development of drug candidates in the top 20 pharmaceutical firms is still based on small …
[图书][B] Anticancer agents from natural products
GM Cragg, DGI Kingston, DJ Newman - 2005 - taylorfrancis.com
Plants, marine organisms, and microorganisms have evolved complex chemical defense
and signaling systems that are designed to protect them from predators and provide other …
and signaling systems that are designed to protect them from predators and provide other …
Metallo-intercalators and metallo-insertors
Since the elucidation of the structure of double helical DNA, the construction of small
molecules that recognize and react at specific DNA sites has been an area of considerable …
molecules that recognize and react at specific DNA sites has been an area of considerable …
O2 Activation by Non-Heme Iron Enzymes
EI Solomon, S Goudarzi, KD Sutherlin - Biochemistry, 2016 - ACS Publications
The non-heme Fe enzymes are ubiquitous in nature and perform a wide range of functions
involving O2 activation. These had been difficult to study relative to heme enzymes; …
involving O2 activation. These had been difficult to study relative to heme enzymes; …
The pathogenesis of bleomycin-induced lung injury in animals and its applicability to human idiopathic pulmonary fibrosis
JD Williamson, LR Sadofsky, SP Hart - Experimental lung research, 2015 - Taylor & Francis
Idiopathic pulmonary fibrosis (IPF) is a devastating disease of unknown etiology, for which
there is no curative pharmacological therapy. Bleomycin, an anti-neoplastic agent that …
there is no curative pharmacological therapy. Bleomycin, an anti-neoplastic agent that …
Analysis of reaction channels for alkane hydroxylation by nonheme iron (IV)–oxo complexes
C Geng, S Ye, F Neese - Angewandte Chemie International …, 2010 - Wiley Online Library
Ever since the discovery of xenobiotic degradation by cytochrome P450,[1] the
functionalization of unactivated CÀH bonds has been a focal point of experimental and …
functionalization of unactivated CÀH bonds has been a focal point of experimental and …
Kinetic analysis of amino acid radicals formed in H2O2-driven CuI LPMO reoxidation implicates dominant homolytic reactivity
SM Jones, WJ Transue, KK Meier… - Proceedings of the …, 2020 - National Acad Sciences
Lytic polysaccharide monooxygenases (LPMOs) have been proposed to react with both O 2
and H 2 O 2 as cosubstrates. In this study, the H 2 O 2 reaction with reduced Hypocrea …
and H 2 O 2 as cosubstrates. In this study, the H 2 O 2 reaction with reduced Hypocrea …
Design of artificial metallonucleases with oxidative mechanism
Q Jiang, N Xiao, P Shi, Y Zhu, Z Guo - Coordination Chemistry Reviews, 2007 - Elsevier
The rational design of artificial metallonucleases capable of cleaving DNA in a controllable
manner is highly desired due to their potential application in biology and medicine. This …
manner is highly desired due to their potential application in biology and medicine. This …