Structure, function, and pharmacology of glutamate receptor ion channels
Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
[HTML][HTML] AMPA receptor trafficking and LTP: Carboxy-termini, amino-termini and TARPs
J Díaz-Alonso, RA Nicoll - Neuropharmacology, 2021 - Elsevier
AMPA receptors (AMPARs) are fundamental elements in excitatory synaptic transmission
and synaptic plasticity in the CNS. Long term potentiation (LTP), a form of synaptic plasticity …
and synaptic plasticity in the CNS. Long term potentiation (LTP), a form of synaptic plasticity …
Molecular mechanism of ligand gating and opening of NMDA receptor
Glutamate transmission and activation of ionotropic glutamate receptors are the fundamental
means by which neurons control their excitability and neuroplasticity. The N-methyl-d …
means by which neurons control their excitability and neuroplasticity. The N-methyl-d …
Glioma synapses recruit mechanisms of adaptive plasticity
The role of the nervous system in the regulation of cancer is increasingly appreciated. In
gliomas, neuronal activity drives tumour progression through paracrine signalling factors …
gliomas, neuronal activity drives tumour progression through paracrine signalling factors …
Modulation of GluA2–γ5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2
SP Gangwar, LY Yen, MV Yelshanskaya… - Nature Structural & …, 2023 - nature.com
Synaptic complexes of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)
receptors (AMPARs) with auxiliary subunits mediate most excitatory neurotransmission and …
receptors (AMPARs) with auxiliary subunits mediate most excitatory neurotransmission and …
Hippocampal AMPA receptor assemblies and mechanism of allosteric inhibition
AMPA-selective glutamate receptors mediate the transduction of signals between the
neuronal circuits of the hippocampus. The trafficking, localization, kinetics and …
neuronal circuits of the hippocampus. The trafficking, localization, kinetics and …
A Noelin-organized extracellular network of proteins required for constitutive and context-dependent anchoring of AMPA-receptors
S Boudkkazi, J Schwenk, N Nakaya, A Brechet… - Neuron, 2023 - cell.com
Information processing and storage in the brain rely on AMPA-receptors (AMPARs) and their
context-dependent dynamics in synapses and extra-synaptic sites. We found that distribution …
context-dependent dynamics in synapses and extra-synaptic sites. We found that distribution …
Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor
AMPA glutamate receptors (AMPARs), the primary mediators of excitatory
neurotransmission in the brain, are either GluA2 subunit-containing and thus Ca2+ …
neurotransmission in the brain, are either GluA2 subunit-containing and thus Ca2+ …
Subsynaptic positioning of AMPARs by LRRTM2 controls synaptic strength
Recent evidence suggests that nano-organization of proteins within synapses may control
the strength of communication between neurons in the brain. The unique subsynaptic …
the strength of communication between neurons in the brain. The unique subsynaptic …
AMPA receptor structure and auxiliary subunits
A Kamalova, T Nakagawa - The Journal of physiology, 2021 - Wiley Online Library
Fast excitatory synaptic transmission in the mammalian brain is largely mediated by AMPA‐
type ionotropic glutamate receptors (AMPARs), which are activated by the neurotransmitter …
type ionotropic glutamate receptors (AMPARs), which are activated by the neurotransmitter …