Nicotine exacerbates diabetic nephropathy through upregulation of Grem1 expression

J Chen, H Xiao, R Xue, V Kumar, R Aslam, SF Mehdi… - Molecular …, 2023 - Springer
Background Diabetic nephropathy (DN) is a major complication of diabetes mellitus. Clinical
reports indicate that smoking is a significant risk factor for chronic kidney disease, and the …

Rewired pathways and disrupted pathway crosstalk in schizophrenia transcriptomes by multiple differential coexpression methods

H Yu, Y Guo, J Chen, X Chen, P Jia, Z Zhao - Genes, 2021 - mdpi.com
Transcriptomic studies of mental disorders using the human brain tissues have been limited,
and gene expression signatures in schizophrenia (SCZ) remain elusive. In this study, we …

Conditional transcriptional relationships may serve as cancer prognostic markers

H Yu, L Wang, D Chen, J Li, Y Guo - BMC Medical Genomics, 2021 - Springer
Background While most differential coexpression (DC) methods are bound to quantify a
single correlation value for a gene pair across multiple samples, a newly devised approach …

RNA editing affects cis‐regulatory elements and predicts adverse cancer survival

YM Wu, Y Guo, H Yu, T Guo - Cancer Medicine, 2021 - Wiley Online Library
Background RNA editing exerts critical impacts on numerous biological processes and thus
are implicated in crucial human phenotypes, including tumorigenesis and prognosis. While …

Novel targets in renal fibrosis based on bioinformatic analysis

Y Yuan, X Xiong, L Li, P Luo - Frontiers in genetics, 2022 - frontiersin.org
Background: Renal fibrosis is a widely used pathological indicator of progressive chronic
kidney disease (CKD), and renal fibrosis mediates most progressive renal diseases as a …

MetaGSCA: A tool for meta-analysis of gene set differential coexpression

Y Guo, H Yu, H Song, J He, O Oyebamiji… - PLoS computational …, 2021 - journals.plos.org
Analyses of gene set differential coexpression may shed light on molecular mechanisms
underlying phenotypes and diseases. However, differential coexpression analyses of …

A Novel Strategy to Identify Prognosis-Relevant Gene Sets in Cancers

J Pu, H Yu, Y Guo - Genes, 2022 - mdpi.com
Molecular prognosis markers hold promise for improved prediction of patient survival, and a
pathway or gene set may add mechanistic interpretation to their prognostic prediction power …

The International Conference on Intelligent Biology and Medicine 2019 (ICIBM 2019): computational methods and applications in medical genomics

C Zhang, E Mathé, X Ning, Z Zhao, K Wang, L Li… - BMC Medical …, 2020 - Springer
In this editorial, we briefly summarized the International Conference on Intelligent Biology
and Medicine 2019 (ICIBM 2019) that was held on June 9–11, 2019 at Columbus, Ohio …

[PDF][PDF] A Novel Strategy to Identify Prognosis-Relevant Gene Sets in Cancers. Genes 2022, 13, 862

J Pu, H Yu, Y Guo - 2022 - pdfs.semanticscholar.org
Molecular prognosis markers hold promise for improved prediction of patient survival, and a
pathway or gene set may add mechanistic interpretation to their prognostic prediction power …