Rat tail models for the assessment of injectable nucleus pulposus regeneration strategies

MN Barcellona, EE McDonnell, S Samuel… - Jor Spine, 2022 - Wiley Online Library
Back pain is a global epidemiological and socioeconomic problem often associated with
intervertebral disc degeneration; a condition believed to initiate in the nucleus pulposus …

Intranasal or airborne transmission-mediated delivery of an attenuated SARS-CoV-2 protects Syrian hamsters against new variants

CB Stauft, P Selvaraj, F D'Agnillo, CA Meseda… - Nature …, 2023 - nature.com
Detection of secretory antibodies in the airway is highly desirable when evaluating mucosal
protection by vaccines against a respiratory virus, such as the severe acute respiratory …

The 6-hydroxydopamine rat model of Parkinson's disease

RP Guimarães, DL Ribeiro, KB Dos Santos… - JoVE (Journal of …, 2021 - jove.com
Motor symptoms of Parkinson's disease (PD)-bradykinesia, akinesia, and tremor at rest-are
consequences of the neurodegeneration of dopaminergic neurons in the substantia nigra …

Anesthesia protocol for ear surgery in Wistar rats (animal research)

A Bhatia, PP Saikia, B Dkhar… - Animal Models and …, 2022 - Wiley Online Library
Objective To formulate an anesthesia protocol for safe and satisfactory anesthesia for ear
surgery in rats. Methods The rats were anesthetized with xylazine (10 mg/kg body weight) …

Organization of the Subdiaphragmatic vagus nerve and its connection with the celiac plexus and the ovaries in the female rat

ME Rivera-Castro, CF Pastelín, J Bravo-Benítez… - Brain Sciences, 2023 - mdpi.com
Communication between the ovaries and the central nervous system occurs by peripheral
innervation through the celiac plexus, superior ovarian nerve, and ovarian plexus nerve. The …

In vivo evaluation of retinal ganglion cells and optic nerve's integrity in large animals by multi-modality analysis

Y Zhang, S Zhang, Y Xia, Y Ji, W Jiang, M Li… - Experimental Eye …, 2020 - Elsevier
Large animal models of optic nerve injury are essential for translating novel findings into
effective therapies due to their similarity to humans in many respects. However, most current …

Commonly used anesthetics modify alcohol and (-)-trans-delta9-tetrahydrocannabinol in vivo effects on rat cerebral arterioles

S Mysiewicz, B Hibl, A Dopico, A Bukiya - BMC anesthesiology, 2023 - Springer
Background Ethyl alcohol and cannabis are widely used recreational substances with
distinct effects on the brain. These drugs increase accidental injuries requiring treatment …

Emerging Anesthetic Nanomedicines: Current State and Challenges

S Zhang, Y Wang, S Zhang, C Huang… - International Journal …, 2023 - Taylor & Francis
Anesthetics, which include both local and general varieties, are a unique class of drugs
widely utilized in clinical surgery to alleviate pain and promote relaxation in patients …

O-GlcNAcylation levels remain stable regardless of the anaesthesia in healthy rats

T Dupas, A Vergnaud, T Pelé, A Blangy-Letheule… - Scientific Reports, 2024 - nature.com
Anaesthetics are used daily in human and veterinary medicine as well as in scientific
research. Anaesthetics have an impact on cell homeostasis especially through modulation …

Combined mutations in nonstructural protein 14, envelope, and membrane proteins mitigate the neuropathogenicity of SARS-CoV-2 Omicron BA. 1 in K18-hACE2 …

K Sangare, S Liu, P Selvaraj, CB Stauft, MF Starost… - mSphere, 2024 - journals.asm.org
We previously reported that mutations outside the spike protein play a role in the attenuation
of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron BA. 1 …