Diverse drug design strategies viz. molecular hybridization, substituent installation, scaffold
hopping, isosteric replacement, high-throughput screening, induction and separation of …

Current cancer therapy can be effective, but the development of drug resistant disease is the
usual outcome. These drugs can eliminate most of the tumor burden but often fail to …

The prognosis for patients with colorectal cancer (CRC) remains worse than expected due to
metastasis, recurrence, and resistance to chemotherapy. Colorectal cancer stem cells …

The Wnt/β-catenin signalling pathway normally maintains cellular and tissue homeostasis by
regulating cellular differentiation and survival in a controlled manner. An aberrantly …

Melanoma is a malignant skin tumor. This study aimed to explore and assess the effect of
novel biomarkers on the progression of melanoma. Differently expressed genes (DEGs) …

Colorectal cancer (CRC) is the third most common cancer and a leading cause of cancer-
related mortality worldwide. Even with advances in therapy, CRC mortality remains high …

Cancer stem cells (CSCs) represent a subpopulation within tumors that promote cancer
progression, metastasis, and recurrence due to their self-renewal capacity and resistance to …

Background: Aldehyde dehydrogenase class 1 (ALDH1) is an enzyme that is ubiquitously
distributed in adult tissues and may serve as a prognostic marker in various cancer types. In …

Background/purpose Oral squamous cell carcinoma (OSCC), a prevalent head and neck
malignancy, is associated with poor survival rates in advanced stages. According to the …

BACKGROUND Aldehyde (ALDH2) dysfunction has been verified to contribute to human
cancers. AIM To investigate the molecular mechanism and biological function of ALDH2 in …