Morpholine is a heterocycle featured in numerous approved and experimental drugs as well
as bioactive molecules. It is often employed in the field of medicinal chemistry for its …

Monoaminergic pathways are highly responsive to aversive stimuli and play a crucial role in
the control of affect, cognition, endocrine secretion, chronobiotic rhythms, appetite, and …

Morpholine is a frequently used heterocycle in medicinal chemistry and a privileged
structural component of bioactive molecules. This is mainly due to its contribution to a …

There have been significant advances in the treatment of depression since the serendipitous
discovery that modulating monoaminergic neurotransmission may be a pathological …

The serotonin (5-hydroxytryptamine, 5-HT) receptors have conventionally been divided into
seven subfamilies, most of which have several subtypes. Among them, 5-HT2A receptor is …

Major depressive disorder (MDD) is the leading cause of disability worldwide. The serotonin
hypothesis may be the model of MDD pathophysiology with the most support. The majority of …

Rationale: Tolerance to delay of reinforcement has been proposed as an important facet of
self-control in both animals and man. Poor self-control, leading to impulsive behaviour, can …

The serotonergic (5-HT) system has been widely implicated in the pathophysiology of Major
Depressive Disorder (MDD). Although the 5-HT system is a popular target for drug therapy in …

[11C] P943 is a new radioligand recently developed to image and quantify serotonin 5-
Hydroxytryptamine (5-HT1B) receptors with positron emission tomography (PET). The …

The purpose of the present study was to investigate the effects of the selective 5-HT 1B
receptor agonist CP 94253, the selective 5-HT 1B receptor antagonist SB 216641, and the 5 …