The MYC gene which consists of 3 paralogs, C-MYC, N-MYC and L-MYC, is one of the most
frequently deregulated driver genes in human cancer. Because of its high prevalence of …

Breast cancer is the most commonly occurring cancer in women. There were over two-
million new cases in world in 2018. It is the second leading cause of death from cancer in …

Single-cell RNA sequencing (scRNA-seq) distinguishes cell types, states and lineages
within the context of heterogeneous tissues. However, current single-cell data cannot …

Intratumoral heterogeneity is a major ongoing challenge in the effective therapeutic targeting
of cancer. Accumulating evidence suggests that a fraction of cells within a tumor termed …

Cell identity is largely determined by its transcriptional profile. In tumour, deregulation of
transcription factor expression and/or activity enables cancer cell to acquire a stem-like state …

Myc is a powerful transcription factor implicated in epigenetic reprogramming, cellular
plasticity, and rapid growth as well as tumorigenesis. Cancer in skeletal muscle is extremely …

Background Human cytomegalovirus (HCMV) infection has been actively implicated in
complex neoplastic processes. Beyond oncomodulation, the molecular mechanisms that …

Non-small-cell lung cancer (NSCLC) is the most common lung cancer subtype and accounts
for more than 80% of all lung cancer cases. Epidermal growth factor receptor (EGFR) …

Purpose: Although chemotherapies kill most cancer cells, stem cell–enriched survivors seed
metastasis, particularly in triple-negative breast cancers (TNBC). TNBCs arise from and are …

Cancer stem cells (CSCs) are distinct subpopulations of cancer cells with stem cell-like
abilities and are more resilient to chemotherapy, causing tumor relapse. Mitophagy, a …