Various aspects of calcium signaling in the regulation of apoptosis, autophagy, cell proliferation, and cancer
Calcium (Ca2+) is a major second messenger in cells and is essential for the fate and
survival of all higher organisms. Different Ca2+ channels, pumps, or exchangers regulate …
survival of all higher organisms. Different Ca2+ channels, pumps, or exchangers regulate …
Ion channels in cancer: are cancer hallmarks oncochannelopathies?
N Prevarskaya, R Skryma, Y Shuba - Physiological reviews, 2018 - journals.physiology.org
Genomic instability is a primary cause and fundamental feature of human cancer. However,
all cancer cell genotypes generally translate into several common pathophysiological …
all cancer cell genotypes generally translate into several common pathophysiological …
The calcium–cancer signalling nexus
GR Monteith, N Prevarskaya… - Nature Reviews …, 2017 - nature.com
The calcium signal is a powerful and multifaceted tool by which cells can achieve specific
outcomes. Cellular machinery important in tumour progression is often driven or influenced …
outcomes. Cellular machinery important in tumour progression is often driven or influenced …
[HTML][HTML] Targeting calcium signaling in cancer therapy
C Cui, R Merritt, L Fu, Z Pan - Acta pharmaceutica sinica B, 2017 - Elsevier
The intracellular calcium ions (Ca 2+) act as second messenger to regulate gene
transcription, cell proliferation, migration and death. Accumulating evidences have …
transcription, cell proliferation, migration and death. Accumulating evidences have …
Animal models of inflammation for screening of anti-inflammatory drugs: implications for the discovery and development of phytopharmaceuticals
Inflammation is one of the common events in the majority of acute as well as chronic
debilitating diseases and represent a chief cause of morbidity in today's era of modern …
debilitating diseases and represent a chief cause of morbidity in today's era of modern …
Ca2+ fluxes and cancer
Ca 2+ ions are key second messengers in both excitable and non-excitable cells. Owing to
the rather pleiotropic nature of Ca 2+ transporters and other Ca 2+-binding proteins …
the rather pleiotropic nature of Ca 2+ transporters and other Ca 2+-binding proteins …
ORAI2 promotes gastric cancer tumorigenicity and metastasis through PI3K/Akt signaling and MAPK-dependent focal adhesion disassembly
The ubiquitous second messenger Ca2+ has long been recognized as a key regulator in
cell migration. Locally confined Ca2+, in particular, is essential for building front-to-rear …
cell migration. Locally confined Ca2+, in particular, is essential for building front-to-rear …
Crosstalk between calcium and reactive oxygen species signaling in cancer
The interplay between Ca 2+ and reactive oxygen species (ROS) signaling pathways is well
established, with reciprocal regulation occurring at a number of subcellular locations. Many …
established, with reciprocal regulation occurring at a number of subcellular locations. Many …
[HTML][HTML] Plasma membrane calcium channels in cancer: Alterations and consequences for cell proliferation and migration
N Déliot, B Constantin - Biochimica et Biophysica Acta (BBA) …, 2015 - Elsevier
The study of calcium channels in molecular mechanisms of cancer transformation is still a
novel area of research. Several studies, mostly conducted on cancer cell lines, however …
novel area of research. Several studies, mostly conducted on cancer cell lines, however …
Stim and Orai proteins in neuronal Ca2+ signaling and excitability
Stim1 and Orai1 are ubiquitous proteins that have long been known to mediate Ca2+
release-activated Ca2+ (CRAC) current (ICRAC) and store-operated Ca2+ entry (SOCE) …
release-activated Ca2+ (CRAC) current (ICRAC) and store-operated Ca2+ entry (SOCE) …