Wnt/β-catenin signaling is implicated in many physiological processes, including
development, tissue homeostasis, and tissue regeneration. In human cancers, Wnt/β-catenin …

Wnt signaling is one of the key cascades regulating development and stemness, and has
also been tightly associated with cancer. The role of Wnt signaling in carcinogenesis has …

The Wnt/β-catenin signaling pathway exerts integral roles in embryogenesis and adult
homeostasis. Aberrant activation of the pathway is implicated in growth-associated diseases …

Recent genomic studies have resulted in an emerging understanding of the role of
chromatin regulators in the development of cancer. EZH2, a histone methyl transferase …

Recently, long noncoding RNAs (lncRNA) have emerged as new gene regulators and
prognostic markers in several cancers, including renal cell carcinoma (RCC). In this study …

Enhancer of zeste homolog 2 (EZH2), a histone methyltransferase and a catalytic
component of PRC2, catalyzes tri-methylation of histone H3 at Lys 27 (H3K27me3) to …

EZH2 mediates both PRC2-dependent gene silencing via catalyzing H3K27me3 and PRC2-
independent transcriptional activation in various cancers. Given its oncogenic role in …

The non-enzymatic functions of target proteins play key roles in the regulation of various cell
signaling pathways and are closely related to numerous human diseases. However …

Abstract Polycomb repressive complex 2 (PRC2) is the epigenetic regulator that induces
histone H3 lysine 27 methylation (H3K27me3) and silences specific gene transcription …

Aberrant regulation of Wnt signaling is a common theme seen across many tumor types.
Decades of research have unraveled the epigenetic and genetic alterations that result in …