Class D β-lactamases are composed of 14 families and the majority of the member enzymes
are included in the OXA family. The genes for class D β-lactamases are frequently identified …

The discovery of penicillin by Alexander Fleming marked a new era for modern medicine,
allowing not only the treatment of infectious diseases, but also the safe performance of life …

Controlling the selectivity of a reaction is critical for target-oriented synthesis. Accessing
complementary selectivity profiles enables divergent synthetic strategies, but is challenging …

Antibiotic resistance in pathogens is extensively studied, and yet little is known about how
antibiotic resistance genes of typical gut bacteria influence microbiome dynamics. Here, we …

The carbapenem-hydrolyzing class D β-lactamases OXA-23 and OXA-24/40 have emerged
worldwide as causative agents for β-lactam antibiotic resistance in Acinetobacter species …

The spread of antibiotic resistant bacteria is a global threat that shakes the foundations of
modern healthcare. β-Lactamases are enzymes that confer resistance to β-lactam antibiotics …

Class D β-lactamases capable of hydrolyzing last-resort carbapenem antibiotics represent a
major challenge for treatment of bacterial infections. Wide dissemination of these enzymes …

The threat posed by the chromosomally encoded class D β-lactamase of Acinetobacter
baumannii (OXA-51/66) has been unclear, in part because of its relatively low affinity and …

OXA-239 is a class D carbapenemase isolated from an Acinetobacter baumannii strain
found in Mexico. This enzyme is a variant of OXA-23 with three amino acid substitutions in or …

Carbapenems are potent β-lactams with activity against extended-spectrum
cephalosporinases and β-lactamases. These antibiotics, derived from thienamycn, a …