The transmission of a complete set of chromosomes to daughter cells during cell division is
vital for development and tissue homeostasis. The spindle assembly checkpoint (SAC) …

The spindle assembly checkpoint (SAC) is a surveillance mechanism that promotes
accurate chromosome segregation in mitosis. The checkpoint senses the attachment state of …

Kinetochores are molecular machines that power chromosome segregation during the
mitotic and meiotic cell divisions of all eukaryotes. Aristotle explains how we think we have …

Open (O) and closed (C) topologies of HORMA-domain proteins are respectively associated
with inactive and active states of fundamental cellular pathways. The HORMA protein O …

Chromosome biorientation on the mitotic spindle is prerequisite to errorless genome
inheritance. CENP‐E (kinesin‐7) and dynein–dynactin (DD), microtubule motors with …

Liquid–liquid phase separation (LLPS) of biomolecules drives the formation of subcellular
compartments with distinct physicochemical properties. These compartments, free of lipid …

The efficacy of current antimitotic cancer drugs is limited by toxicity in highly proliferative
healthy tissues. A cancer-specific dependency on the microtubule motor protein KIF18A …

The microtubule minus-end-directed motility of cytoplasmic dynein 1 (dynein), arguably the
most complex and versatile cytoskeletal motor, is harnessed for diverse functions, such as …

In metazoans, a≈ 1 megadalton (MDa) multiprotein complex comprising the dynein–
dynactin adaptor Spindly and the ROD–Zwilch–ZW10 (RZZ) complex is the building block of …

The spindle assembly checkpoint (SAC) is a cellular surveillance mechanism that functions
to ensure accurate chromosome segregation during mitosis. Macromolecular complexes …