Synaptic abnormalities are a cardinal feature of Alzheimer's disease (AD) that are known to
arise as the disease progresses. A growing body of evidence suggests that pathological …

Brain-derived neurotrophic factor (BDNF) is one of the most distributed and extensively
studied neurotrophins in the mammalian brain. BDNF signals through the tropomycin …

As one of the most prevalent neurotrophic factors in the central nervous system (CNS), brain-
derived neurotrophic factor (BDNF) plays a significant role in CNS injury by binding to its …

Here we report that synaptic and extrasynaptic NMDA (N-methyl-D-aspartate) receptors
have opposite effects on CREB (cAMP response element binding protein) function, gene …

Background: Mood disorders, consisting of unipolar and bipolar depression, are complex
diseases characterized by depressed mood and anhedonia. These core symptoms are …

During fasting and vigorous exercise, a shift of brain cell energy substrate utilization from
glucose to the ketone 3‐hydroxybutyrate (3 OHB) occurs. Studies have shown that 3 OHB …

Ca 2+ entry through the NMDA subtype of glutamate receptors has the power to determine
whether neurons survive or die. Too much NMDA receptor activity is harmful to neurons–but …

Microglia in the dorsal horn of the spinal cord are increasingly recognized as being crucial in
the pathogenesis of pain hypersensitivity after injury to a peripheral nerve. It is known that …

Alpha‐linolenic acid (ALA) is plant‐based essential omega‐3 polyunsaturated fatty acids
that must be obtained through the diet. This could explain in part why the severe deficiency …

The transcription factor NF-κB has diverse functions in the nervous system, depending on
the cellular context. NF-κB is constitutively activated in glutamatergic neurons. Knockout of …