Over the last 17 years, there has been a remarkable increase in scientific research
concerning chronic traumatic encephalopathy (CTE). Since the publication of NINDS–NIBIB …

Pathological accumulation of abnormally phosphorylated tau protein in astrocytes is a
frequent, but poorly characterized feature of the aging brain. Its etiology is uncertain, but its …

The ordered assembly of tau protein into filaments characterizes several neurodegenerative
diseases, which are called tauopathies. It was previously reported that, by cryo-electron …

Chronic traumatic encephalopathy is a progressive tauopathy that occurs as a consequence
of repetitive mild traumatic brain injury. We analysed post-mortem brains obtained from a …

Tauopathies are clinically, morphologically and biochemically heterogeneous
neurodegenerative diseases characterized by the deposition of abnormal tau protein in the …

Reactive astrocytes were identified as a component of senile amyloid plaques in the cortex
of Alzheimer's disease (AD) patients several decades ago. However, their role in AD …

The benefits of regular exercise, physical fitness and sports participation on cardiovascular
and brain health are undeniable. Physical activity reduces the risk for cardiovascular …

Astrocytes have essential roles in the central nervous system and are also implicated in the
pathogenesis of neurodegenerative disease. Forming non‐overlapping domains, astrocytes …

Neurodegenerative diseases are characterised by neuronal loss and cerebral deposition of
proteins with altered physicochemical properties. The major proteins are amyloid-β (Aβ), tau …

Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disease that
occurs in association with repetitive traumatic brain injury experienced in sport and military …