The centromere is the region of the chromosome that directs its segregation in mitosis and
meiosis. Although the functional importance of the centromere has been appreciated for …

Animal development and lifetime potential exploit a balance between the stability and
plasticity of cellular identity. Within the nucleus, this is controlled by an interplay involving …

Centromeres are essential for chromosome segregation and are specified epigenetically by
the presence of the histone H3 variant CENP-A. In flies and humans, replenishment of the …

Nucleosome-to-protamine exchange during mammalian spermiogenesis is essential for
compaction and protection of paternal DNA. It is interesting that, depending on the species …

Precise spatiotemporal regulation of gene expression is of paramount importance for
eukaryotic development. The maternal-to-zygotic transition (MZT) during early …

Within the nucleus, the interplay between lineage-specific transcription factors and
chromatin dynamics defines cellular identity. Control of this interplay is necessary to properly …

The H3 histone variant CENP-A is an epigenetic marker critical for the centromere identity
and function. However, the precise regulation of the spatiotemporal deposition and …

Many stem cells utilize asymmetric cell division (ACD) to produce a self-renewed stem cell
and a differentiating daughter cell. How non-genic information could be inherited …

Background Centromeres depend on chromatin containing the conserved histone H3
variant CENP-A for function and inheritance, while the role of centromeric DNA repeats …

Centromeres control genetic inheritance by directing chromosome segregation but are not
genetically encoded themselves. Rather, centromeres are defined by nucleosomes …