The cytokine IL-10 is a key anti-inflammatory mediator ensuring protection of a host from
over-exuberant responses to pathogens and microbiota, while playing important roles in …

Traumatic spinal cord injury (SCI) is a life changing neurological condition with substantial
socioeconomic implications for patients and their care-givers. Recent advances in medical …

Spinal cord injury (SCI) creates an inflammatory microenvironment characterized by
damage-associated molecular patterns (DAMPs) and immune cell activation that exacerbate …

Spinal cord injury (SCI) is a devastating neurological disorder that affects thousands of
individuals each year. Over the past decades an enormous progress has been made in our …

Background The inflammatory response is critical to fight insults, such as pathogen invasion
or tissue damage, but if not resolved often becomes detrimental to the host. A growing body …

Traumatic optic neuropathy (TON) refers to a pathological condition caused by a direct or
indirect insult to the optic nerves, which often leads to a partial or permanent vision deficit …

There is increasing interest in and evidence for altered immune factors in the etiology and
pathophysiology of schizophrenia. Stimulated by various epidemiological findings reporting …

Spinal cord injury (SCI) consists of a two-steps process involving a primary mechanical
injury followed by an inflammatory process and apoptosis. Secondary insult is characterized …

Recently, it was found that microglia regulated synaptic remodeling of the developing brain,
but their mechanisms have not been well understood. In this study, the action of microglia on …

Spinal cord injury results in a life‐disrupting series of deleterious interconnected
mechanisms encompassed by the primary and secondary injury. These events are mediated …