Integrins are considered the main cell-adhesion transmembrane receptors that play
multifaceted roles as extracellular matrix (ECM)-cytoskeletal linkers and transducers in …

The amyloid-β oligomer (AβO) hypothesis was introduced in 1998. It proposed that the brain
damage leading to Alzheimer's disease (AD) was instigated by soluble, ligand-like AβOs …

Abstract Alzheimer's disease (AD), the most common form of dementia, is characterized by
the accumulation of amyloid β (Aβ) and hyperphosphorylated tau protein aggregates …

Astrocytes are highly efficient homeostatic glial cells playing a crucial role in optimal brain
functioning and homeostasis. Astrocytes respond to changes in brain homoeostasis …

Reactive oxygen species (ROS) are pervasive signaling molecules in biological systems. In
humans, a lack of ROS causes chronic and extreme bacterial infections, while uncontrolled …

In neurodegenerative diseases, extracellular vesicles (EVs) transfer pathogenic molecules
and are consequently involved in disease progression. We have investigated the proteomic …

NADPH oxidases (NOXs) form a family of electron-transporting membrane enzymes whose
main function is reactive oxygen species (ROS) generation. Strong evidence suggests that …

Astrocytes play essential roles in development, homeostasis, injury, and repair of the central
nervous system (CNS). Their development is tightly regulated by distinct spatial and …

Small guanosine triphosphatases (GTPases) of the Ras superfamily are key regulators of
many key cellular events such as proliferation, differentiation, cell cycle regulation …

Amyloid‐β (Aβ) dysmetabolism is tightly associated with pathological processes in
Alzheimer's disease (AD). Currently, it is thought that, in addition to Aβ fibrils that give rise to …