Until recently, computational tools were mainly used to explain chemical reactions after
experimental results were obtained. With the rapid development of software and hardware …

C− H bond functionalization has been one of most important subject in chemistry. The
carbene transfer reaction is one of the most straightforward and efficient approaches for site …

The C–H functionalization reaction of N-heterocycles with an unprotected N–H group is one
of the most step-economic strategies to introduce functional groups without the need for …

Iron porphyrin carbenes constitute a new frontier of species with considerable synthetic
potential. Exquisitely engineered myoglobin and cytochrome P450 enzymes can generate …

A concise synthesis of functionalized indene derivatives via the gold (I)-catalysed cascade C–
H functionalization/conia-ene type reaction of electron-rich aromatics with o-alkynylaryl α …

The catalytic functionalization of the Csp2–H bond of benzene by means of the insertion of
the CHCO2Et group from ethyl diazoacetate (N2 CHCO2Et) has been studied with the …

The mechanism of Rh2 (S‐NTTL) 4 catalyzed carbene insertion into C (3)− H of indole is
investigated using DFT methods. Since the commonly accepted enol mechanism cannot …

Chiral quinacridines react up to four times, step‐by‐step, with α‐diazomalonates under RuII
and RhII catalysis. By selecting the catalyst,[CpRu (CH3CN) 3][PF6](Cp= cyclopentadienyl) …

Phenothiazine is an important structural motif in pharmaceuticals and advanced functional
organic materials. However, the C− H functionalization reaction of N‐protected …

The reaction of diazo compounds with transition-metal carbenes is an efficient way to
achieve the functionalization of chemical bonds in organic molecules, especially for the C–H …