Combinatorial substitution of phosphate groups on the inositol ring gives rise to a plethora of
inositol phosphates (InsPs) and inositol pyrophosphates (PP-InsPs). These small molecules …

Simple Summary It has long been known that breast tumors harbor various types of
microbes. However, it was little known where these tumor-resident microbes came from and …

Introduction Preeclampsia (PE) is a severe obstetrical syndrome characterized by new-onset
hypertension and proteinuria and it is often associated with fetal intrauterine growth …

Activated Foxp3+ regulatory T (Treg) cells differentiate into effector Treg (eTreg) cells to
maintain peripheral immune homeostasis and tolerance. T cell receptor (TCR)–mediated …

Inositol phosphates are water-soluble intracellular signaling molecules found in eukaryotes
from yeasts to mammals, which are synthesized by a complex network of enzymes including …

Inositol polyphosphate multikinase (IPMK) is a pleiotropic enzyme responsible for the
production of inositol polyphosphates and phosphoinositide. IPMK in macrophages was …

Objectives: Identify the etiology of X-linked agammaglobulinemia. Review the evaluation
process for X-linked agammaglobulinemia. Outline the treatment and management options …

The occurrence of immune effector cells in the tissue microenvironment during neoplastic
progression is critical in determining tumor growth outcomes. On the other hand, tumors may …

Bacterial infection presents severe challenge to tilapia farming, which is largely influenced
by water temperature. However, how water temperature determines tilapias' survival to …

Abstract The Tec-family kinase Btk contains a lipid-binding Pleckstrin homology and Tec
homology (PH-TH) module connected by a proline-rich linker to a 'Src module', an SH3-SH2 …