Abstract Background Transcription factor 7-like 2 (TCF7L2) has been shown to be
associated with type 2 diabetes mellitus (T2MD) in multiple ethnic groups in the past two …

The role of the Wnt signaling pathway in metabolic homeostasis has drawn our intensive
attention, especially after the genome-wide association study discovery that certain …

To identify genetic factors contributing to type 2 diabetes (T2D), we performed large-scale
meta-analyses by using a custom∼ 50,000 SNP genotyping array (the ITMAT-Broad-CARe …

The Wnt signaling pathway was initially discovered for its role in tumorigenesis and the
development of Drosophila and other eukaryotic organisms. The key effector of this pathway …

OBJECTIVE—In recent genome-wide association studies, variants in CDKAL1, SLC30A8,
HHEX, EXT2, IGF2BP2, CDKN2B, LOC387761, and FTO were associated with risk for type 2 …

Abstract Background: In Europeans and populations of European origin, several groups
have recently identified novel type 2 diabetes susceptibility genes, including FTO, SLC30A8 …

Abstract Objective Activation of the Wnt-signaling pathway is known to inhibit differentiation
in adipocytes. However, there is a gap in our understanding of the transcriptional network …

Recently, many new loci associated with type 2 diabetes have been uncovered by genetic
association studies and genome-wide association studies. As more reports are made …

Polymorphism of transcription factor 7-like 2 (TCF7L2) has a link with type 2 diabetes
mellitus (T2DM) through β cell dysfunction that causes defect in blood glucose homeostasis …

AIMS: The prevalence of type 2 diabetes mellitus (DM) among Emirati subjects is one of the
highest in the world. This has been attributed to rising prevalence of obesity acting on …