Cancer therapy has long relied on the rapid proliferation of tumour cells for effective
treatment. However, the lack of specificity in this approach often leads to undesirable side …

This review documents the changing perspectives on the function of fatty-acid synthase and
fatty-acid synthesis in human tumor biology. With the recent discovery that human cancer …

Cancer stem cells (CSCs) are a small and elusive subpopulation of self-renewing cancer
cells with remarkable ability to initiate, propagate, and spread the malignant disease. In …

Compared to normal human tissues, many common human cancers, including carcinoma of
the colon, prostate, ovary, breast, and endometrium, express high levels of fatty acid …

The reorganization of metabolic pathways in cancer facilitates the flux of carbon and
reducing equivalents into anabolic pathways at the expense of oxidative phosphorylation …

Background: Bisphenol A (BPA) is the principal constituent of baby bottles, reusable water
bottles, metal cans, and plastic food containers. BPA exerts estrogen-like activity by …

Abstract Protein kinase B (PKB/Akt) has been shown to play a role in protection from
apoptosis, cell proliferation and cell growth. It is also involved in mediating the effects of …

Despite the remarkable progress in cancer treatment up to now, we are still far from
conquering the disease. The most substantial change after the malignant transformation of …

A biologically aggressive subset of human breast cancers and other malignancies is
characterized by elevated fatty-acid synthase (FAS) enzyme expression, elevated fatty acid …

The expression of fatty acid synthase (FAS), a key lipogenic enzyme and potential target for
antineoplastic therapy, was analyzed in 87 frozen needle biopsies of prostate cancer using …