Microglia, the brain's immune sentinels, have garnered much attention in recent years.
Researchers have begun to identify the manifold roles that these cells play in the central …

The functional contribution of microglia to normal brain development, healthy brain function,
and neurological disorders is increasingly recognized. However, until recently, the nature of …

Microglia play key roles in brain development, homeostasis, and function, and it is widely
assumed that the adult population is long lived and maintained by self-renewal. However …

Hematopoietic stem cell transplantation (HSCT) can replace endogenous microglia with
circulation-derived macrophages but has high mortality. To mitigate the risks of HSCT and …

The P2X7 receptor is a cation channel activated by high concentrations of adenosine
triphosphate (ATP). Upon long-term activation, it complexes with membrane proteins forming …

As the professional phagocytes of the brain, microglia orchestrate the immunological
response and play an increasingly important role in maintaining homeostatic brain functions …

Background: pain is one of the main symptoms of endometriosis and it has a deleterious
effect on a patients' personal and social life. To date, the clinical management of pain …

Inflammation is emerging as a critical mechanism underlying neurological disorders of
various etiologies, yet its role in altering brain function as a consequence of neuroinfectious …

Summary iPSC-derived microglia offer a powerful tool to study microglial homeostasis and
disease-associated inflammatory responses. Yet, microglia are highly sensitive to their …

Microglia, the resident immune cells of the brain, play important roles during development.
Although bi-directional communication between microglia and neuronal progenitors or …