Microglia are the tissue-resident macrophages of the brain and spinal cord. They are critical
players in the development, normal function, and decline of the CNS. Unlike traditional …

C‐type lectin receptors (CLRs) are essential for multicellular existence, having diverse
functions ranging from embryonic development to immune function. One subgroup of CLRs …

Microglia, the brain's resident macrophages, are dynamic CNS custodians with surprising
origins in the extra-embryonic yolk sac. The consequences of their distinct ontogeny are …

Interleukin (IL)-17A is a key driver of inflammation and the principal target of anti-IL-17
therapeutic monoclonal antibodies. IL-17A, and its structurally similar family member IL-17F …

Despite major scientific discoveries and novel therapies over the past four decades, the
treatment outcomes of acute myeloid leukemia (AML), especially in the adult patient …

Macrophages are abundant in the tumor microenvironment (TME), serving as accomplices
to cancer cells for their invasion. Studies have explored the biochemical mechanisms that …

Dendritic cells (DCs) are the most potent professional antigen-presenting cells (APCs),
which play a pivotal role in inducing either inflammatory or tolerogenic response based on …

Malaria represents a major cause of death from infectious disease. Hemozoin is a
Plasmodium-derived product that contributes to progression of cerebral malaria. However …

The ability of myeloid cells to recognize and differentiate endogenous or exogenous ligands
rely on the presence of different transmembrane protein receptors. C-type lectin receptors …

The targeted protein degradation (TPD) technology employing proteolysis-targeting
chimeras (PROTACs) has been widely applied in drug chemistry and chemical biology for …