ERK/MAPK signalling in the developing brain: Perturbations and consequences

JD Iroegbu, OK Ijomone, OM Femi-Akinlosotu… - Neuroscience & …, 2021 - Elsevier
The extracellular regulated kinase/microtubule-associated protein kinase (ERK/MAPK)
signalling pathway transduces signals that cause an alteration in the ongoing metabolic …

[HTML][HTML] The role of environmental trace element toxicants on autism: A medical biogeochemistry perspective

SM Awadh, ZM Yaseen, MS Al-Suwaiyan - … and environmental safety, 2023 - Elsevier
Since genetic factors alone cannot explain most cases of Autism, the environmental factors
are worth investigating as they play an essential role in the development of some cases of …

Early-life lead exposure induces long-term toxicity in the central nervous system: From zebrafish larvae to juveniles and adults

Z Wang, H Zhao, Y Xu, J Zhao, Z Song, Y Bi, Y Li… - Science of the Total …, 2022 - Elsevier
Lead induced neurotoxicity has been extensively investigated. However, the potential
connections between early-life lead exposure and the frequently observed aberrant …

Hydrogen Sulfide (H2S) Signaling as a Protective Mechanism against Endogenous and Exogenous Neurotoxicants

M Aschner, AV Skalny, T Ke… - Current …, 2022 - benthamdirect.com
In view of the significant role of H2S in brain functioning, it is proposed that H2S may also
possess protective effects against adverse effects of neurotoxicants. Therefore, the objective …

Increased serum levels of cadmium are associated with an elevated risk of cardiovascular disease in adults

S Ma, J Zhang, C Xu, M Da, Y Xu, Y Chen… - … Science and Pollution …, 2022 - Springer
Previous studies have determined the effects of exposure to certain heavy metals on
cardiovascular disease (CVD); however, the association between cadmium exposure and …

Neurodevelopmental disorders (NDD) caused by genomic alterations of the ubiquitin-proteasome system (UPS): the possible contribution of immune dysregulation to …

F Ebstein, S Küry, JJ Papendorf… - Frontiers in Molecular …, 2021 - frontiersin.org
Over thirty years have passed since the first description of ubiquitin-positive structures in the
brain of patients suffering from Alzheimer's disease. Meanwhile, the intracellular …

Analysis of whole blood and urine trace elements in children with autism spectrum disorders and autistic behaviors

G Zhao, S Liu, X Gan, J Li, X Wu, S Liu, Y Jin… - Biological trace element …, 2023 - Springer
The relationship between trace elements and neurological development is an emerging
research focus. We performed a case–control study to explore (1) the differences of 13 trace …

Neuroprotective effects of quercetin in pediatric neurological diseases

L Alvarez-Arellano, M Salazar-García, JC Corona - Molecules, 2020 - mdpi.com
Oxidative stress is a crucial event underlying several pediatric neurological diseases, such
as the central nervous system (CNS) tumors, autism spectrum disorder (ASD) and attention …

Mercury and autism Spectrum disorder: Exploring the link through comprehensive review and meta-analysis

A Stojsavljević, N Lakićević, S Pavlović - Biomedicines, 2023 - mdpi.com
Mercury (Hg) is a non-essential trace metal with unique neurochemical properties and
harmful effects on the central nervous system. In this study, we present a comprehensive …

Prenatal folic acid supplements and offspring's autism spectrum disorder: a meta-analysis and meta-regression

X Liu, M Zou, C Sun, L Wu, WX Chen - Journal of autism and …, 2022 - Springer
We systematically reviewed the evidence on the association between maternal folic acid
supplementation and the risk of offspring's autism spectrum disorders (ASD). A total of 10 …