Structural and immunological principles leading to chemically synthesized, multiantigenic, multistage, minimal subunit-based vaccine development
Dedicated to the memory of Professors Henry G. Kunkel and Bruce Merrifield (Rockefeller
University, New York), who introduced us to the fascinating worlds of immunology and …
University, New York), who introduced us to the fascinating worlds of immunology and …
Intimate Molecular Interactions of P. falciparum Merozoite Proteins Involved in Invasion of Red Blood Cells and Their Implications for Vaccine Design
LE Rodriguez, H Curtidor, M Urquiza… - Chemical …, 2008 - ACS Publications
Intimate Molecular Interactions of P. falciparum Merozoite Proteins Involved in Invasion of Red
Blood Cells and Their Implications for Vaccine Design | Chemical Reviews ACS ACS …
Blood Cells and Their Implications for Vaccine Design | Chemical Reviews ACS ACS …
Genetic diversity of vaccine candidate antigens in Plasmodium falciparum isolates from the Amazon basin of Peru
SM Chenet, OLH Branch, AA Escalante, CM Lucas… - Malaria journal, 2008 - Springer
Background Several of the intended Plasmodium falciparum vaccine candidate antigens are
highly polymorphic and could render a vaccine ineffective if their antigenic sites were not …
highly polymorphic and could render a vaccine ineffective if their antigenic sites were not …
Strategies for developing multi‐epitope, subunit‐based, chemically synthesized anti‐malarial vaccines
ME Patarroyo, G Cifuentes, A Bermudez… - Journal of cellular …, 2008 - Wiley Online Library
• Introduction• P. falciparum invasion of RBCs• Merozoite proteins involved in invading
erythrocytes• Erythrocyte proteins involved in merozoite invasion• The state of current …
erythrocytes• Erythrocyte proteins involved in merozoite invasion• The state of current …
Identification of conserved erythrocyte binding regions in members of the Plasmodium falciparum Cys6 lipid raft-associated protein family
Detergent-resistant lipid raft membrane-associated Pf12, Pf38 and Pf41 proteins belong to
the Cys6 family, whose members are implicated in Plasmodium falciparum invasion to …
the Cys6 family, whose members are implicated in Plasmodium falciparum invasion to …
Identifying Plasmodium falciparum merozoite surface antigen 3 (MSP3) protein peptides that bind specifically to erythrocytes and inhibit merozoite invasion
LE Rodríguez, H Curtidor, M Ocampo, J Garcia… - Protein …, 2005 - Wiley Online Library
Receptor–ligand interactions between synthetic peptides and normal human erythrocytes
were studied to determine Plasmodium falciparum merozoite surface protein‐3 (MSP‐3) …
were studied to determine Plasmodium falciparum merozoite surface protein‐3 (MSP‐3) …
Conserved binding regions provide the clue for peptide-based vaccine development: a chemical perspective
Synthetic peptides have become invaluable biomedical research and medicinal chemistry
tools for studying functional roles, ie, binding or proteolytic activity, naturally-occurring …
tools for studying functional roles, ie, binding or proteolytic activity, naturally-occurring …
Plasmodium falciparum TryThrA antigen synthetic peptides block in vitro merozoite invasion to erythrocytes
H Curtidor, M Ocampo, LE Rodríguez, R López… - Biochemical and …, 2006 - Elsevier
Tryptophan–threonine-rich antigen (TryThrA) is a Plasmodium falciparum homologue of
Plasmodium yoelii-infected erythrocyte membrane pypAg-1 antigen. pypAg-1 binds to the …
Plasmodium yoelii-infected erythrocyte membrane pypAg-1 antigen. pypAg-1 binds to the …
Modifying RESA protein peptide 6671 to fit into HLA-DRβ1* pockets induces protection against malaria
MP Alba, LM Salazar, LE Vargas, M Trujillo… - Biochemical and …, 2004 - Elsevier
6671 is a non-immunogenic, conserved high activity red blood cell binding peptide located
between residues 141 and 160 of the Plasmodium falciparum RESA protein. This peptide's …
between residues 141 and 160 of the Plasmodium falciparum RESA protein. This peptide's …
Gamma interferon levels and antibody production induced by two PvMSP-1 recombinant polypeptides are associated with protective immunity against P. vivax in …
CA Barrero, G Delgado, AY Sierra, Y Silva… - Vaccine, 2005 - Elsevier
Effector mechanisms responsible for providing protective immunity against Plasmodium
vivax (Pv) infection were examined in Aotus monkeys vaccinated with two Pv Merozoite …
vivax (Pv) infection were examined in Aotus monkeys vaccinated with two Pv Merozoite …