Prospects for riboswitch discovery and analysis

RR Breaker - Molecular cell, 2011 - cell.com
An expanding number of metabolite-binding riboswitch classes are being discovered in the
noncoding portions of bacterial genomes. Findings over the last decade indicate that …

Catalytic nucleic acids: biochemistry, chemical biology, biosensors, and nanotechnology

L Ma, J Liu - Iscience, 2020 - cell.com
Since the initial discovery of ribozymes in the early 1980s, catalytic nucleic acids have been
used in different areas. Compared with protein enzymes, catalytic nucleic acids are …

Elucidating the molecular architecture of adaptation via evolve and resequence experiments

A Long, G Liti, A Luptak, O Tenaillon - Nature Reviews Genetics, 2015 - nature.com
Evolve and resequence (E&R) experiments use experimental evolution to adapt populations
to a novel environment, then next-generation sequencing to analyse genetic changes. They …

A widespread self-cleaving ribozyme class is revealed by bioinformatics

A Roth, Z Weinberg, AGY Chen, PB Kim… - Nature chemical …, 2014 - nature.com
Ribozymes are noncoding RNAs that promote chemical transformations with rate
enhancements approaching those of protein enzymes. Although ribozymes are likely to …

New classes of self-cleaving ribozymes revealed by comparative genomics analysis

Z Weinberg, PB Kim, TH Chen, S Li, KA Harris… - Nature chemical …, 2015 - nature.com
Enzymes made of RNA catalyze reactions that are essential for protein synthesis and RNA
processing. However, such natural ribozymes are exceedingly rare, as evidenced by the fact …

[图书][B] RNA, the epicenter of genetic information

J Mattick, P Amaral - 2023 - library.oapen.org
The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

Chemistry and biology of self-cleaving ribozymes

RM Jimenez, JA Polanco, A Lupták - Trends in biochemical sciences, 2015 - cell.com
Self-cleaving ribozymes were discovered 30 years ago, but their biological distribution and
catalytic mechanisms are only beginning to be defined. Each ribozyme family is defined by a …

Novel ribozymes: discovery, catalytic mechanisms, and the quest to understand biological function

CE Weinberg, Z Weinberg… - Nucleic acids research, 2019 - academic.oup.com
Small endonucleolytic ribozymes promote the self-cleavage of their own phosphodiester
backbone at a specific linkage. The structures of and the reactions catalysed by members of …

A novel RNA motif mediates the strict nuclear localization of a long noncoding RNA

B Zhang, L Gunawardane, F Niazi… - … and cellular biology, 2014 - Taylor & Francis
The ubiquitous presence of long noncoding RNAs (lncRNAs) in eukaryotes points to the
importance of understanding how their sequences impact function. As many lncRNAs …

Small, highly active DNAs that hydrolyze DNA

H Gu, K Furukawa, Z Weinberg… - Journal of the …, 2013 - ACS Publications
DNA phosphoester bonds are exceedingly resistant to hydrolysis in the absence of chemical
or enzymatic catalysts. This property is particularly important for organisms with large …