Sepsis remains a major cause of morbidity and mortality mainly because of sepsis-induced
multiple organ dysfunction. In contrast to preclinical studies, most clinical trials of promising …

The biology of cells of the mononuclear phagocyte system has been studied extensively in
the mouse. Studies of the pig as an experimental model have commonly been consigned to …

Significance: Traumatic injury elicits a complex, dynamic, multidimensional inflammatory
response that is intertwined with complications such as multiple organ dysfunction and …

Acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS) remain common
complications of sepsis. Unfortunately, development of effective pharmacologic and …

Extracorporeal membrane oxygenation (ECMO) has gained renewed interest in the
treatment of respiratory failure since the advent of the modern polymethylpentene …

Lipopolysaccharide (LPS) is a gram-negative bacterial endotoxin and a major factor that
contributes to multiple organ failure, including heart injury. Myocardial dysfunction in septic …

Background Although there are well-established small-animal sepsis models, the
longitudinal assessment of hemodynamic variables, laboratory values, and blood culture in …

The pathogenetic mechanisms associated to the beneficial effects of mixed venous oxygen
saturation (SvO 2)–guided resuscitation during sepsis are unclear. Our purpose was to …

Highlights•Hematopoietic stem/progenitor cells contribute to blood supply during
infection.•Cytokines, pathogen-associated molecular patterns, and niche cells coordinately …

Background Fluid therapy in veterinary medicine is pivotal for treating various conditions in
pigs; however, standard solutions, such as Hartmann's solution, may not optimally align with …