BACKGROUND Nature has evolved elegant mechanisms to regulate the physical distance
between molecules, or proximity, for a wide variety of purposes. Whether it is activation of …

The phytohormone auxin has been shown to be of pivotal importance in growth and
development of land plants. The underlying molecular players involved in auxin …

Protein knockdown using the auxin-inducible degron (AID) technology is useful to study
protein function in living cells because it induces rapid depletion, which makes it possible to …

Studying the role of essential proteins is dependent upon a method for rapid inactivation, in
order to study the immediate phenotypic consequences. Auxin-inducible degron (AID) …

Experimental manipulation of protein abundance in living cells or organisms is an essential
strategy for investigation of biological regulatory mechanisms. Whereas powerful techniques …

The auxin-inducible degron (AID) system has emerged as a powerful tool to conditionally
deplete proteins in a range of organisms and cell types. Here, we describe a toolkit to …

Fusion of inducible degradation signals, so‐called degrons, to cellular proteins is an elegant
method of controlling protein levels in vivo. Recently, a degron system relying on the plant …

Inducible degradation is a powerful approach for identifying the function of a specific protein
or protein complex. Recently, a plant auxin-inducible degron (AID) system has been shown …

Controlling protein expression using a degron is advantageous because the protein of
interest can be rapidly depleted in a reversible manner. We pioneered the development of …

Heterochromatin that depends on histone H3 lysine 9 methylation (H3K9me) renders
embedded genes transcriptionally silent,–. In the fission yeast Schizosaccharomyces …