Prostaglandin endoperoxide H synthases-1 and-2, commonly called cyclooxygenases-1
and-2 (COX-1 and-2), catalyze the committed step in prostaglandin biosynthesis—the …

Adipose tissue–secreted extracellular vesicles (EVs) containing microRNAs (miRNAs)
convey intercellular message signaling. The biogenesis of EV-miRNAs from perivascular …

Abstract Background Yunnan Baiyao (YNBY) is a traditional Chinese medicine formulae,
which has the functions of hemostasis, activating blood circulation and removing blood …

Prostanoids are short-lived autocrine and paracrine signaling molecules involved in a wide
range of biological functions. They have been shown to be intimately involved in many …

Bradykinin (BK) has been proposed to modulate urinary bladder functions and implicated in
the pathophysiology of detrusor overactivity. The present study aims to elucidate the …

Evidence is scarce to guide the use of nonsteroidal anti-inflammatory drugs (NSAIDs) to
mitigate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine–related …

Abstract Both cyclooxygenase (COX)-1 and COX-2, encoded by Ptgs1 and Ptgs2, function
coordinately during inflammation. But the relative contributions and compensations of COX …

Abstract Ca2+/calmodulin-dependent protein kinase II γ (CAMKIIγ) has been identified as a
potential target for treating cancer. Based on our previous study of berbamine (BBM) as a …

The participation of cyclooxygenase (COX) in embryo implantation and parturition has been
studied extensively. However, the distinct role of the two COX isoforms in these processes …

Squamous cell carcinoma (SCC) remains a main cause of mortality in patients with neck and
head cancers, with poor prognosis and increased prevalence despite of available therapies …