The fibroblast growth factor (FGF) family is composed of 18 secreted signaling proteins
consisting of canonical FGFs and endocrine FGFs that activate four receptor tyrosine …

Voltage-gated sodium channels (Navs) are critical determinants of cellular excitability.
These ion channels exist as large heteromultimeric structures and their activity is tightly …

Among the FGF proteins, the least characterized superfamily is the group of fibroblast growth
factor homologous factors (FHFs). To date, the main role of FHFs has been primarily seen in …

The finely tuned regulation of neuronal firing relies on the integrity of ion channel
macromolecular complexes. Minimal disturbances of these tightly regulated networks can …

Glycogen synthase kinase 3β (GSK3) is a multifaceted serine/threonine (S/T) kinase
expressed in all eukaryotic cells. GSK3β is highly enriched in neurons in the central nervous …

FGF homologous factors (FHFs) are the least described group of fibroblast growth factors
(FGFs). The FHF subfamily consists of four proteins: FGF11, FGF12, FGF13, and FGF14 …

Background Excess tumor necrosis factor (TNF) is implicated in the pathogenesis of
hyperinflammatory experimental cerebral malaria (eCM), including gliosis, increased levels …

Protein/protein interactions (PPI) play crucial roles in neuronal functions. Yet, their potential
as drug targets for brain disorders remains underexplored. The fibroblast growth factor 14 …

Glycogen synthase kinase 3beta (GSK-3β) is an enzyme with a variety of cellular functions
in addition to the regulation of glycogen metabolism. In the central nervous system, different …

Background Cognitive impairment in humans with Alzheimer's disease (AD) and in animal
models of Aβ-pathology can be ameliorated by treatments with the nuclear receptor …