Computational fluid dynamic modeling of the lymphatic system: a review of existing models and future directions
TD Jayathungage Don, S Safaei… - … and Modeling in …, 2024 - Springer
Historically, research into the lymphatic system has been overlooked due to both a lack of
knowledge and limited recognition of its importance. In the last decade however, lymphatic …
knowledge and limited recognition of its importance. In the last decade however, lymphatic …
Stability of protein pharmaceuticals: Recent advances
MC Manning, RE Holcomb, RW Payne… - Pharmaceutical …, 2024 - Springer
There have been significant advances in the formulation and stabilization of proteins in the
liquid state over the past years since our previous review. Our mechanistic understanding of …
liquid state over the past years since our previous review. Our mechanistic understanding of …
Modeling large-volume subcutaneous injection of monoclonal antibodies with anisotropic porohyperelastic models and data-driven tissue layer geometries
Subcutaneous injection of therapeutic monoclonal antibodies (mAbs) has become one of
the fastest-growing fields in the pharmaceutical industry. The transport and mechanical …
the fastest-growing fields in the pharmaceutical industry. The transport and mechanical …
Computational modeling of the effect of skin pinch and stretch on subcutaneous injection of monoclonal antibodies using autoinjector devices
Subcutaneous injection of monoclonal antibodies (mAbs) has experienced unprecedented
growth in the pharmaceutical industry due to its benefits in patient compliance and cost …
growth in the pharmaceutical industry due to its benefits in patient compliance and cost …
Transport and distribution of biotherapeutics in different tissue layers after subcutaneous injection
The subcutaneous injection is the main route of administration for monoclonal antibodies
(mAbs) and several other biotherapeutics due to the patient comfort and cost-effectiveness …
(mAbs) and several other biotherapeutics due to the patient comfort and cost-effectiveness …
Modeling drug transport and absorption in subcutaneous injection of monoclonal antibodies: Impact of tissue deformation, devices, and physiology
The pharmaceutical industry has experienced a remarkable increase in the use of
subcutaneous injection of monoclonal antibodies (mAbs), attributed mainly to its advantages …
subcutaneous injection of monoclonal antibodies (mAbs), attributed mainly to its advantages …
Lymphatic uptake of biotherapeutics through a 3D hybrid discrete-continuum vessel network in the skin tissue
Subcutaneous administration is a common approach for the delivery of biotherapeutics,
which is achieved mainly through the absorption across lymphatic vessels. In this paper, the …
which is achieved mainly through the absorption across lymphatic vessels. In this paper, the …
Stabilized isogeometric formulation of the multi-network poroelasticity and transport model (mpet2) for subcutaneous injection of monoclonal antibodies
The MPET 2 model couples the multi-network poroelastic theory (MPET) with solute
transport equations and provides predictions of the material deformation, fluid dynamics …
transport equations and provides predictions of the material deformation, fluid dynamics …
A biomimetic chip to assess subcutaneous bioavailability of monoclonal antibodies in humans
Subcutaneous (subQ) injection is a common route for delivering biotherapeutics, wherein
pharmacokinetics is largely influenced by drug transport in a complex subQ tissue …
pharmacokinetics is largely influenced by drug transport in a complex subQ tissue …
A multi-scale numerical study of monoclonal antibodies uptake by initial lymphatics after subcutaneous injection
This paper studies the transport of monoclonal antibodies through skin tissue and initial
lymphatics, which impacts the pharmacokinetics of monoclonal antibodies. Our model …
lymphatics, which impacts the pharmacokinetics of monoclonal antibodies. Our model …