Poly (ADP-ribose) polymerase inhibition: past, present and future
The process of poly (ADP-ribosyl) ation and the major enzyme that catalyses this reaction,
poly (ADP-ribose) polymerase 1 (PARP1), were discovered more than 50 years ago. Since …
poly (ADP-ribose) polymerase 1 (PARP1), were discovered more than 50 years ago. Since …
Base excision repair
HE Krokan, M Bjørås - Cold Spring Harbor perspectives …, 2013 - cshperspectives.cshlp.org
Base excision repair (BER) corrects DNA damage from oxidation, deamination and
alkylation. Such base lesions cause little distortion to the DNA helix structure. BER is …
alkylation. Such base lesions cause little distortion to the DNA helix structure. BER is …
[HTML][HTML] PARPs in lipid metabolism and related diseases
PARPs and tankyrases (TNKS) represent a family of 17 proteins. PARPs and tankyrases
were originally identified as DNA repair factors, nevertheless, recent advances have shed …
were originally identified as DNA repair factors, nevertheless, recent advances have shed …
Multifaceted role of PARP-1 in DNA repair and inflammation: pathological and therapeutic implications in cancer and non-cancer diseases
S Pazzaglia, C Pioli - Cells, 2019 - mdpi.com
PARP-1 (poly (ADP-ribose)-polymerase 1), mainly known for its protective role in DNA
repair, also regulates inflammatory processes. Notably, defects in DNA repair and chronic …
repair, also regulates inflammatory processes. Notably, defects in DNA repair and chronic …
PARP-1 cleavage fragments: signatures of cell-death proteases in neurodegeneration
GV Chaitanya, JS Alexander, PP Babu - Cell communication and signaling, 2010 - Springer
The normal function of poly (ADP-ribose) polymerase-1 (PARP-1) is the routine repair of
DNA damage by adding poly (ADP ribose) polymers in response to a variety of cellular …
DNA damage by adding poly (ADP ribose) polymers in response to a variety of cellular …
ADP-ribosylation, a multifaceted posttranslational modification involved in the control of cell physiology in health and disease
B Lüscher, M Bütepage, L Eckei, S Krieg… - Chemical …, 2018 - ACS Publications
Posttranslational modifications (PTMs) regulate protein functions and interactions. ADP-
ribosylation is a PTM, in which ADP-ribosyltransferases use nicotinamide adenine …
ribosylation is a PTM, in which ADP-ribosyltransferases use nicotinamide adenine …
PARP inhibition: PARP1 and beyond
Recent findings have thrust poly (ADP-ribose) polymerases (PARPs) into the limelight as
potential chemotherapeutic targets. To provide a framework for understanding these recent …
potential chemotherapeutic targets. To provide a framework for understanding these recent …
On PAR with PARP: cellular stress signaling through poly (ADP-ribose) and PARP-1
X Luo, WL Kraus - Genes & development, 2012 - genesdev.cshlp.org
Cellular stress responses are mediated through a series of regulatory processes that occur
at the genomic, transcriptional, post-transcriptional, translational, and post-translational …
at the genomic, transcriptional, post-transcriptional, translational, and post-translational …
Coordination of DNA single strand break repair
R Abbotts, DM Wilson III - Free Radical Biology and Medicine, 2017 - Elsevier
The genetic material of all organisms is susceptible to modification. In some instances, these
changes are programmed, such as the formation of DNA double strand breaks during …
changes are programmed, such as the formation of DNA double strand breaks during …
Caspases: the executioners of apoptosis
GM Cohen - Biochemical Journal, 1997 - portlandpress.com
Apoptosis is a major form of cell death, characterized initially by a series of stereotypic
morphological changes. In the nematode Caenorhabditis elegans, the gene ced-3 encodes …
morphological changes. In the nematode Caenorhabditis elegans, the gene ced-3 encodes …