The selenol (-SeH) group of selenocysteine (SeCys), a cysteine analogue and a more
potent nucleophile, has often been considered as a potential target of toxic trace metals and …

Cancer cells adapt to their inherently increased oxidative stress through activation of the
glutathione (GSH) and thioredoxin (TXN) systems. Inhibition of both of these systems …

Metals have been considered for millennia to have medicinal values. With the advent of
modern medicine, many metal-based drugs have proven to be highly effective in the clinic …

Proteasomes are attractive emerging targets for anti-cancer therapies. Auranofin (Aur), a
gold-containing compound clinically used to treat rheumatic arthritis, was recently approved …

The solution behavior of auranofin, Et3PAuCl and Et3PAuI, as well as their interactions with
hen egg white lysozyme, single strand oligonucleotide, and ds-DNA were comparatively …

The clinically established gold drug Auranofin was reacted individually with a group of
representative proteins, namely ubiquitin, ribonuclease A, carbonic anhydrase …

Selenoenzymes, containing a selenocysteine (Sec) residue, fulfill important roles in biology.
The mammalian thioredoxin reductase selenoenzymes are key regulators of antioxidant …

N-Heterocyclic carbene (NHC) gold (I) complexes offer great prospects in medicinal
chemistry as antiproliferative, anticancer, and antibacterial agents. However, further …

Thioredoxin (Trx) and GSH are the major thiol antioxidants protecting cells from oxidative
stress-induced cytotoxicity. Redox states of Trx and GSH have been used as indicators of …

Trypanothione reductase (TR) is considered to be one of the best targets to find new drugs
against Leishmaniasis. This enzyme is fundamental for parasite survival in the host since it …