In Vitro, Ex Vivo, and in vivo models for the study of Pemphigus

R Lotti, CG Atene, ED Zanfi, M Bertesi… - International Journal of …, 2022 - mdpi.com
Pemphigus is a life-threatening autoimmune disease. Several phenotypic variants are part
of this family of bullous disorders. The disease is mainly mediated by pathogenic …

Beyond the skin: B cells in pemphigus vulgaris, tolerance and treatment

AL Strandmoe, J Bremer, GFH Diercks… - British Journal of …, 2024 - academic.oup.com
Pemphigus vulgaris (PV) is a rare autoimmune bullous disease characterized by blistering
of the skin and mucosa owing to the presence of autoantibodies against the desmosome …

Immunostimulatory effects of Toll‐like receptor ligands as adjuvants in establishing a novel mouse model for pemphigus vulgaris

C Gao, M Liu, Y Xin, Y Zeng, H Yang… - Clinical and …, 2024 - Wiley Online Library
Background The meticulous selection of appropriate vaccine adjuvants is crucial for
optimizing immune responses. Traditionally, pemphigus vulgaris (PV), an autoimmune …

Desmoglein-Specific B-Cell− Targeted Single-Cell Analysis Revealing Unique Gene Regulation in Patients with Pemphigus

S Egami, T Watanabe, A Fukushima-Nomura… - Journal of Investigative …, 2023 - Elsevier
Autoreactive B cells are assumed to play a critical role in pemphigus; however, the
characteristics of these cells are not yet fully understood. In this study, 23 pemphigus …

[HTML][HTML] Unraveling Mechanisms of Autoimmune Skin Blistering: Applying Single-Cell Transcriptomics to Pemphigus B Cells

CM Hammers - Journal of Investigative Dermatology, 2023 - Elsevier
Autoimmunity against the skin is typically attributed to autoantibodies (with their
corresponding B cells producing them) or T cells that react against autoantigens, resulting in …