Critical illness polyneuropathies (CIP) and myopathies (CIM) are common complications of
critical illness. Several weakness syndromes are summarized under the term intensive care …

Patients requiring prolonged intensive care are at high risk for multiple organ failure and
death. Insulin resistance and hyperglycemia accompany critical illness, and the severity of …

Background Sepsis-induced multiple organ failure is the major cause of mortality and
morbidity in critically ill patients. However, the precise mechanisms by which this dysfunction …

Sepsis and other critical illnesses produce a biphasic inflammatory, immune, hormonal, and
metabolic response. The acute phase is marked by an abrupt rise in the secretion of so …

Although sepsis is the major cause of mortality and morbidity in the critically ill, precise
mechanism (s) causing multiorgan dysfunction remain unclear. Findings of impaired oxygen …

Mitochondria play a central role in cell life and cell death. An increasing number of studies
place mitochondrial dysfunction at the heart of disease, most notably in the heart and the …

Until now, catecholamines were the drugs of choice to treat hypotension during shock states.
Catecholamines, however, also have marked metabolic effects, particularly on glucose …

Background Maintenance of normoglycaemia by use of insulin reduces morbidity and
mortality of patients in surgical intensive care. Studies on mitochondrial function in critical …

Objective: To describe temporal changes in mitochondrial function during the septic process,
including the recovery phase. Design: Literature review. Subjects: Clinical studies and …

An emerging and important site of action for nitric oxide (NO) within cells is the mitochondrial
inner membrane, where NO binds to and inhibits members of the electron transport chain …