Bromodomains are protein modules that bind to acetylated lysine residues. Their interaction
with histone proteins suggests that they function as “readers” of histone lysine acetylation, a …

Proteins of the bromodomain and extra-terminal (BET) domain family are epigenetic readers
that bind acetylated histones through their bromodomains to regulate gene transcription …

Bromodomains, small protein modules that recognize acetylated lysine on histones, play a
significant role in the epigenome, where they function as “readers” that ultimately determine …

The profound efficacy, yet associated toxicity of pan-BET inhibitors is well documented. The
possibility of an ameliorated safety profile driven by significantly selective (> 100-fold) …

Herein, a series of 2, 3-dihydrobenzofurans have been developed as highly potent bromo
and extra-terminal domain (BET) inhibitors with 1000-fold selectivity for the second …

A number of reports have recently been published describing the discovery and optimization
of bromo and extraterminal inhibitors which are selective for the second bromodomain …

Background: Atopic Dermatitis (AD) is a chronic relapsing dermatosis associated with itch,
sleep disturbance and poor quality of life. Treatment of AD includes the use of emollients …

Herein we present a Zn-ProPhenol-catalyzed double Mannich reaction between ynones and
imines that generates 1, 3-diamines in excellent yield as well as diastereo-and …