Macrophages are the most abundant immune cells within the synovial joints, and also the
main innate immune effector cells triggering the initial inflammatory responses in the …

Skeletal disorders are among the leading debilitating factors affecting millions of people
worldwide. The use of stem cells for tissue repair has raised many promises in various …

Skin aging is a multifaceted process that involves intrinsic and extrinsic mechanisms that
lead to various structural and physiological changes in the skin. Intrinsic aging is associated …

Adipose-derived stem cells (ASCs) secrete many cytokines, proteins, growth factors, and
extracellular vesicles with beneficial outcomes that can be used in regenerative medicine. It …

Adult stem cells that are tightly regulated by the specific microenvironment, or the stem cell
niche, function to maintain tissue homeostasis and regeneration after damage. This …

Diseases that jeopardize the musculoskeletal system and cause chronic impairment are
prevalent throughout the Western world. In Germany alone,~ 1.8 million patients suffer from …

With the insufficient satisfaction rates and high cost of operative treatment for osteoarthritis
(OA), alternatives have been sought. Furthermore, the inability of current medications to …

Ischemic diseases are characterized by reduced blood supply to a tissue or an organ due to
obstruction of blood vessels. The most serious and most common ischemic diseases include …

Bone-marrow-derived mesenchymal stem cells (MSCs) are of growing interest for the
treatment of diabetic wound healing. However, they are often associated with poor …

Exogenous dual delivery of progenitor cell population and therapeutic growth factors (GFs)
is one of alternative tissue engineering strategies for osteochondral tissue regeneration. In …