Nanoparticles for oral delivery: Design, evaluation and state-of-the-art

AA Date, J Hanes, LM Ensign - Journal of Controlled Release, 2016 - Elsevier
The oral route is a preferred method of drug administration, though achieving effective drug
delivery and minimizing off-target side effects is often challenging. Formulation into …

Poly (lactic acid)/poly (lactic-co-glycolic acid)-based microparticles: An overview

P Blasi - Journal of Pharmaceutical Investigation, 2019 - Springer
Background Poly (glycolic acid), poly (lactic acid) and poly (lactic-co-glycolic acid) were
approved by the United States Food and Drug Administration (FDA) in the 1970s as …

Long-acting PLGA microspheres: advances in excipient and product analysis toward improved product understanding

B Wan, Q Bao, D Burgess - Advanced drug delivery reviews, 2023 - Elsevier
Poly (lactic-co-glycolic acid)(PLGA) microspheres are a sustained-release drug delivery
system with several successful commercial products used for the treatment of a variety of …

Clinically established biodegradable long acting injectables: an industry perspective

CI Nkanga, A Fisch, M Rad-Malekshahi… - Advanced drug delivery …, 2020 - Elsevier
Long acting injectable formulations have been developed to sustain the action of drugs in
the body over desired periods of time. These delivery platforms have been utilized for both …

Drug release from in situ forming implants and advances in release testing

X Wang, DJ Burgess - Advanced Drug Delivery Reviews, 2021 - Elsevier
In situ forming implants, defined as liquid formulations that generate solid or semisolid
depots following administration, have shown a range of advantages in drug delivery. This …

Rational formulation and industrial manufacturing of lipid-based complex injectables: Landmarks and trends

M Biscaia-Caleiras, NA Fonseca, AS Lourenço… - Journal of Controlled …, 2024 - Elsevier
Lipid-based complex injectables are renowned for their effectiveness in delivering drugs,
with many approved products. While significant strides have been made in formulating …

[HTML][HTML] Comparative evaluation of rivastigmine permeation from a transdermal system in the Franz cell using synthetic membranes and pig ear skin with in vivo-in …

A Simon, MI Amaro, AM Healy, LM Cabral… - International journal of …, 2016 - Elsevier
In the present study, in vitro permeation experiments in a Franz diffusion cell were performed
using different synthetic polymeric membranes and pig ear skin to evaluate a rivastigmine …

Recent advances in lipid-based long-acting injectable depot formulations

R Sharma, S Yadav, V Yadav, J Akhtar, O Katari… - Advanced drug delivery …, 2023 - Elsevier
Long-acting injectable (LAIs) delivery systems sustain the drug therapeutic action in the
body, resulting in reduced dosage regimen, toxicity, and improved patient compliance. Lipid …

Challenges and opportunities in the development of complex generic long-acting injectable drug products

MN O'Brien, W Jiang, Y Wang, DM Loffredo - Journal of controlled release, 2021 - Elsevier
Long-acting injectable (LAI) drug products enable the controlled release of a drug over an
extended duration of time to improve the therapeutic effect, safety profile, or administration of …

Current trends in PLGA based long-acting injectable products: The industry perspective

OS Muddineti, A Omri - Expert Opinion on Drug Delivery, 2022 - Taylor & Francis
Introduction Poly (lactic-co-glycolic acid)(PLGA) has been used in many long-acting drug
formulations, which have been approved by the US Food and Drug Administration (FDA) …