The kidney plays a crucial role in acid-base homeostasis. In the distal nephron, α-
intercalated cells contribute to urinary acid (H+) secretion and β-intercalated cells …

Abstract Pendrin (SLC26A4) is an anion exchanger from the SLC26 transporter family which
is mutated in human patients affected by Pendred syndrome, an autosomal recessive …

Background The secretin receptor (SCTR) is functionally expressed in the basolateral
membrane of the β-intercalated cells of the kidney cortical collecting duct and stimulates …

Secretin is a key hormone of the intestinal phase of digestion which activates pancreatic,
bile duct and Brunner gland HCO3− secretion. Recently, the secretin receptor (SCTR) was …

Cellular and organism survival depends upon the regulation of pH, which is regulated by
highly specialized cell membrane transporters, the solute carriers (SLC)(For a …

Both KCC3b and KCC3a seem to be needed for maintaining cell volume during enhanced
inward cotransport of Na-glucose in proximal tubule and Na-HCO 3 in intercalated cells. In …

Metabolic acidosis‐induced kidney injury (MAKI) is asymptomatic and lack of clinical
biomarkers in early stage, but rapidly progresses to severe renal fibrosis and ultimately …

Urinary tract infections affect more than 1 in 2 women during their lifetime. Among these,
more than 10% of patients carry antibiotic-resistant bacterial strains, highlighting the urgent …

The hormone renin is produced in the kidney by the juxtaglomerular cells. It is the rate-
limiting factor in the circulating renin–angiotensin–aldosterone system (RAAS), which …

This review summarizes methods to study kidney intercalated cell (IC) function ex vivo.
While important for acid-base homeostasis, IC dysfunction is often not recognized clinically …