The role of sleep in regulating structural plasticity and synaptic strength: implications for memory and cognitive function
Dendritic spines are the major sites of synaptic transmission in the central nervous system.
Alterations in the strength of synaptic connections directly affect the neuronal …
Alterations in the strength of synaptic connections directly affect the neuronal …
Sleep deprivation, oxidative stress and inflammation
Adequate sleep is essential for normal brain function, especially during early life
developmental stages as postnatal brain maturation occurs during the critical period of …
developmental stages as postnatal brain maturation occurs during the critical period of …
Sleep loss drives acetylcholine-and somatostatin interneuron–mediated gating of hippocampal activity to inhibit memory consolidation
Sleep loss disrupts consolidation of hippocampus-dependent memory. To characterize
effects of learning and sleep loss, we quantified activity-dependent phosphorylation of …
effects of learning and sleep loss, we quantified activity-dependent phosphorylation of …
[HTML][HTML] Primed to sleep: the dynamics of synaptic plasticity across brain states
It is commonly accepted that brain plasticity occurs in wakefulness and sleep. However, how
these different brain states work in concert to create long-lasting changes in brain circuitry is …
these different brain states work in concert to create long-lasting changes in brain circuitry is …
The function (s) of sleep
Sleep is a highly conserved phenomenon in endotherms, and therefore it must serve at least
one basic function across this wide range of species. What that function is remains one of …
one basic function across this wide range of species. What that function is remains one of …
[HTML][HTML] Sleep deprivation and the epigenome
Sleep deprivation disrupts the lives of millions of people every day and has a profound
impact on the molecular biology of the brain. These effects begin as changes within a …
impact on the molecular biology of the brain. These effects begin as changes within a …
[HTML][HTML] Linking network activity to synaptic plasticity during sleep: hypotheses and recent data
C Puentes-Mestril, SJ Aton - Frontiers in neural circuits, 2017 - frontiersin.org
Research findings over the past two decades have supported a link between sleep states
and synaptic plasticity. Numerous mechanistic hypotheses have been put forth to explain …
and synaptic plasticity. Numerous mechanistic hypotheses have been put forth to explain …
The tired hippocampus: the molecular impact of sleep deprivation on hippocampal function
Highlights•Restoring hippocampal cAMP levels prevents sleep deprivation-induced memory
deficits.•Blocking hippocampal PDE4A5 function prevents memory deficits caused by sleep …
deficits.•Blocking hippocampal PDE4A5 function prevents memory deficits caused by sleep …
Hippocampal reactivation extends for several hours following novel experience
New memories are believed to be consolidated over several hours of post-task sleep. The
reactivation or “replay” of hippocampal cell assemblies has been proposed to provide a key …
reactivation or “replay” of hippocampal cell assemblies has been proposed to provide a key …
[HTML][HTML] The trilateral interactions between mammalian target of rapamycin (mTOR) signaling, the circadian clock, and psychiatric disorders: an emerging model
Abstract Circadian (~ 24 h) rhythms in physiology and behavior are evolutionarily conserved
and found in almost all living organisms. The rhythms are endogenously driven by daily …
and found in almost all living organisms. The rhythms are endogenously driven by daily …