The eukaryotic transcription apparatus synthesizes a staggering diversity of RNA molecules.
The labour of nuclear gene transcription is, therefore, divided among multiple DNA …

Immediate-early genes (IEGs) can be activated and transcribed within minutes after
stimulation, without the need for de novo protein synthesis, and they are stimulated in …

Abstract Design of de novo synthetic regulatory DNA is a promising avenue to control gene
expression in biotechnology and medicine. Using mutagenesis typically requires screening …

Transcription of eukaryotic protein-coding genes commences with the assembly of a
conserved initiation complex, which consists of RNA polymerase II (Pol II) and the general …

Summary mRNAs are regulated by nucleotide modifications that influence their cellular fate.
Two of the most abundant modified nucleotides are N 6-methyladenosine (m 6 A), found …

Plants, unlike animals, exhibit a very high degree of plasticity in their growth and
development and employ diverse strategies to cope with the variations during diurnal cycles …

Organisms are constantly exposed to a wide range of environmental changes, including
both short-term changes during their lifetime and longer-term changes across generations …

The RNA polymerase II core promoter is a structurally and functionally diverse
transcriptional regulatory element. There are two main strategies for transcription initiation …

An important tenet of evolutionary developmental biology (“evo devo”) is that adaptive
mutations affecting morphology are more likely to occur in the cis-regulatory regions than in …

The promoter region is located near the transcription start sites and regulates transcription
initiation of the gene by controlling the binding of RNA polymerase. Thus, promoter region …