The malaria parasite, Plasmodium falciparum, harbours a relict plastid known as the
'apicoplast'. The discovery of the apicoplast ushered in an exciting new prospect for drug …

Malaria continues to be a potentially fatal threat to almost half of the world's population. In
light of this threat, the armory to fight this disease is rather limited. Resistance against the …

Malaria is a devastating infection caused by protozoa of the genus Plasmodium. Drug
resistance is widespread, no new chemical class of antimalarials has been introduced into …

Several classes of antibiotics exert antimalarial activity. The mechanisms of action of
antibiotics against malaria parasites have been unclear, and prior studies have led to …

Heme is an essential cofactor for aerobic organisms. Its redox chemistry is central to a
variety of biological functions mediated by hemoproteins. In blood stages, malaria parasites …

Intracellular parasites of the phylum Apicomplexa harbor a plastid-like organelle called
apicoplast that is the most reduced organelle of this type known. Due to the medical …

For over a century, heme metabolism has been recognized to play a central role during
intraerythrocytic infection by Plasmodium parasites, the causative agent of malaria …

Genome‐scale metabolic reconstructions can serve as important tools for hypothesis
generation and high‐throughput data integration. Here, we present a metabolic network …

The malaria parasite Plasmodium possesses a relict, non-photosynthetic plastid known as
the apicoplast. The apicoplast is essential for parasite survival, and harbors several plant …

Several antibiotics possess antimalarial properties, although the mechanisms by which they
kill malaria parasites have been poorly understood. Recent data suggest that the target for …