Antimicrobial use and resistance in plant agriculture: a one health perspective

SA Miller, JP Ferreira, JT LeJeune - Agriculture, 2022 - mdpi.com
Bactericides, fungicides, and other pesticides play an important role in the management of
plant diseases. However, their use can result in residues on plants and in the environment …

The global problem of antifungal resistance: prevalence, mechanisms, and management

DS Perlin, R Rautemaa-Richardson… - The Lancet infectious …, 2017 - thelancet.com
All serious fungal infections need appropriate antifungal therapy for successful patient
outcome. Only a few classes of antifungal drugs are available, so the emergence of …

Drug-resistant fungi: an emerging challenge threatening our limited antifungal armamentarium

A Arastehfar, T Gabaldón, R Garcia-Rubio, JD Jenks… - Antibiotics, 2020 - mdpi.com
The high clinical mortality and economic burden posed by invasive fungal infections (IFIs),
along with significant agricultural crop loss caused by various fungal species, has resulted in …

Emerging fungal infections: new patients, new patterns, and new pathogens

DZP Friedman, IS Schwartz - Journal of Fungi, 2019 - mdpi.com
The landscape of clinical mycology is constantly changing. New therapies for malignant and
autoimmune diseases have led to new risk factors for unusual mycoses. Invasive …

Azole-resistant Aspergillus fumigatus in the environment: Identifying key reservoirs and hotspots of antifungal resistance

C Burks, A Darby, L Gómez Londoño… - PLoS …, 2021 - journals.plos.org
Aspergillus fumigatus is an opportunistic human pathogen that causes aspergillosis, a
spectrum of environmentally acquired respiratory illnesses. It has a cosmopolitan distribution …

Azole Resistance in Aspergillus fumigatus: Can We Retain the Clinical Use of Mold-Active Antifungal Azoles?

PE Verweij, A Chowdhary… - Clinical Infectious …, 2016 - academic.oup.com
Azole resistance in Aspergillus fumigatus has emerged as a global health problem.
Although the number of cases of azole-resistant aspergillosis is still limited, resistance …

Emerging threats in antifungal-resistant fungal pathogens

D Sanglard - Frontiers in medicine, 2016 - frontiersin.org
The use of antifungal drugs in the therapy of fungal diseases can lead to the development of
antifungal resistance. Resistance has been described for virtually all antifungal agents in …

Mechanisms of antifungal drug resistance

LE Cowen, D Sanglard… - Cold Spring …, 2015 - perspectivesinmedicine.cshlp.org
Antifungal therapy is a central component of patient management for acute and chronic
mycoses. Yet, treatment choices are restricted because of the sparse number of antifungal …

How to bolster the antifungal pipeline

DW Denning, MJ Bromley - Science, 2015 - science.org
About 1.2 billion people worldwide are estimated to suffer from a fungal disease (,). Most are
infections of the skin or mucosa, which respond readily to therapy, but a substantial minority …

Clinical implications of globally emerging azole resistance in Aspergillus fumigatus

JF Meis, A Chowdhary, JL Rhodes… - … of the Royal …, 2016 - royalsocietypublishing.org
Aspergillus fungi are the cause of an array of diseases affecting humans, animals and
plants. The triazole antifungal agents itraconazole, voriconazole, isavuconazole and …