ABL-family proteins comprise one of the best conserved branches of the tyrosine kinases.
Each ABL protein contains an SH3-SH2-TK (Src homology 3–Src homology 2–tyrosine …

Chronic Myeloid Leukemia (CML) is a clonal disease characterized by the presence of the
Philadelphia (Ph+) chromosome and its oncogenic product, BCR-ABL, a constitutively active …

Tyrosine kinases belong to a family of enzymes that mediate the movement of the phosphate
group to tyrosine residues of target protein, thus transmitting signals from the cell surface to …

Given its relative rarity, it may at first seem surprising that chronic myeloid leukemia (CML)
has garnered so much attention over the last decade. Yet, the advances in molecular …

Anaplastic large-cell lymphoma (ALCL) was initially recognized on the basis of morphologic
features and the consistent expression of CD30. It then became evident that the majority of …

Src family kinases such as Lyn are important signaling intermediaries, relaying and
modulating different inputs to regulate various outputs, such as proliferation, differentiation …

Targeting the tyrosine kinase activity of Bcr-Abl is an attractive therapeutic strategy in chronic
myeloid leukemia (CML) and in Bcr-Abl–positive acute lymphoblastic leukemia. Whereas …

Although only 5000 new cases of chronic myeloid leukemia (CML) were seen in the United
States in 2009, this neoplasm continues to make scientific headlines year-after-year …

Dasatinib is an inhibitor of BCR-ABL and SRC-family kinases for patients with imatinib-
resistant or-intolerant chronic myelogenous leukemia (CML). In this international phase II …

Tyrosine kinases regulate a broad variety of physiological cell processes, including
metabolism, growth, differentiation and apoptosis. Abnormal tyrosine kinase activity disturbs …