Beneficial outcomes of omega-6 and omega-3 polyunsaturated fatty acids on human health: An update for 2021

I Djuricic, PC Calder - Nutrients, 2021 - mdpi.com
Oxidative stress and inflammation have been recognized as important contributors to the risk
of chronic non-communicable diseases. Polyunsaturated fatty acids (PUFAs) may regulate …

Omega-3 fatty acids and inflammatory processes: from molecules to man

PC Calder - Biochemical Society Transactions, 2017 - portlandpress.com
Inappropriate, excessive or uncontrolled inflammation contributes to a range of human
diseases. Inflammation involves a multitude of cell types, chemical mediators and …

[HTML][HTML] Metabolic modulation of immune checkpoints and novel therapeutic strategies in cancer

Y Wang, Y Wang, Y Ren, Q Zhang, P Yi… - Seminars in cancer …, 2022 - Elsevier
Cytotoxic T-lymphocyte–associated antigen-4 (CTLA-4) or programmed death-1 (PD-
1)/programmed death-ligand 1 (PD-L1)–based immune checkpoint inhibitors (ICIs) have led …

Marine omega-3 fatty acids and inflammatory processes: Effects, mechanisms and clinical relevance

PC Calder - Biochimica et Biophysica Acta (BBA)-Molecular and …, 2015 - Elsevier
Inflammation is a condition which contributes to a range of human diseases. It involves a
multitude of cell types, chemical mediators, and interactions. Eicosapentaenoic acid (EPA) …

Omega‐3 polyunsaturated fatty acids and inflammatory processes: nutrition or pharmacology?

PC Calder - British journal of clinical pharmacology, 2013 - Wiley Online Library
Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are n‐3 fatty acids found in
oily fish and fish oil supplements. These fatty acids are able to inhibit partly a number of …

The influence of dietary fatty acids on immune responses

U Radzikowska, AO Rinaldi, Z Çelebi Sözener… - Nutrients, 2019 - mdpi.com
Diet-derived fatty acids (FAs) are essential sources of energy and fundamental structural
components of cells. They also play important roles in the modulation of immune responses …

Dietary factors and low-grade inflammation in relation to overweight and obesity

PC Calder, N Ahluwalia, F Brouns, T Buetler… - British Journal of …, 2011 - cambridge.org
Low-grade inflammation is a characteristic of the obese state, and adipose tissue releases
many inflammatory mediators. The source of these mediators within adipose tissue is not …

[HTML][HTML] Mechanisms of action of (n-3) fatty acids

PC Calder - The Journal of nutrition, 2012 - Elsevier
Abstract (n-3) PUFA are a family of biologically active fatty acids. The simplest member of
this family, a-linolenic acid, can be converted to the more biologically active very long-chain …

Mechanisms of obesity-induced inflammation and insulin resistance: insights into the emerging role of nutritional strategies

MA McArdle, OM Finucane, RM Connaughton… - Frontiers in …, 2013 - frontiersin.org
Obesity and associated chronic inflammation initiate a state of insulin resistance (IR). The
secretion of chemoattractants such as MCP-1 and MIF and of cytokines IL-6, TNF-α, and IL …

Long-term intake of dietary fat and risk of ulcerative colitis and Crohn's disease

AN Ananthakrishnan, H Khalili, GG Konijeti… - Gut, 2014 - gut.bmj.com
Introduction Dietary fats influence intestinal inflammation and regulate mucosal immunity.
Data on the association between dietary fat and risk of Crohn's disease (CD) and ulcerative …