Recent research has demonstrated that the non-coding genome plays a key role in genetic
programming and gene regulation during development as well as in health and …

Successful treatment of cancer depends on early diagnosis and effective monitoring of
patients' response to therapy. Traditional tools based on tumor biopsies lack the sensitivity …

Breast cancer is a major health problem that affects one in eight women worldwide. As such,
detecting breast cancer at an early stage anticipates better disease outcome and prolonged …

Exosomes are nano-vesicles present in the circulation that are involved in cell-to-cell
communication and regulation of different biological processes. MicroRNAs (miRNAs) are …

Hemolysis is conventionally defined as membrane disruption of red blood cells and other
blood cells that is accompanied by subsequent release of intracellular components into the …

Epigenetic modifications and regulators represent potential molecular elements which
control relevant physiological and pathological features, thereby contributing to the natural …

Abstract STUDY QUESTION Can plasma miRNAs be used for the non-invasive diagnosis of
endometriosis in infertile women? SUMMARY ANSWER miRNA-based diagnostic models …

Liquid biopsy-based biomarkers, such as microRNAs, represent valuable tools for patient
management, but often do not make it to integration in the clinic. We aim to explore issues …

Toll-like receptors (TLRs) play a crucial role in the innate immune response. Although
endosomal TLR7 recognizes single-stranded RNAs, their endogenous RNA ligands have …

The etiology of Parkinson's disease (PD) is poorly understood, and is strongly suspected to
include both genetic and environmental factors. In this context, it is essential to investigate …