Extensive experimental animal studies and epidemiological observations have shown that
environmental influences during early development affect the risk of later pathophysiological …

Cardiovascular diseases are among the leading causes of death worldwide. Reactive
oxygen species (ROS) can act as damaging molecules but also represent central hubs in …

Hypoxia is one of the most common and severe challenges to the maintenance of
homeostasis. Oxygen sensing is a property of all tissues, and the response to hypoxia is …

Adverse environments during the fetal and neonatal development period may permanently
program physiology and metabolism, and lead to increased risk of diseases in later life …

It is now recognized that the quality of the fetal environment during early development is
important in programming cardiovascular health and disease in later life. Fetal hypoxia is …

The capacity to remember our past experiences and organize our future draws on a number
of cognitive processes that allow our brain to form and store neural representations that can …

The liver is intimately connected to inflammation, which is the innate defense system of the
body for removing harmful stimuli and participates in the hepatic wound-healing response …

Introduction The anti-cancer medication doxorubicin (Dox) is largely restricted in clinical
usage due to its significant cardiotoxicity. The only medication approved by the FDA for Dox …

It has been shown that ROS (reactive oxygen species, superoxide and hydrogen peroxide)
regulate major epigenetic processes, DNA methylation and histone acetylation, although the …

Aims The mechanisms of heart failure remain largely elusive. The present study determined
a causative role of DNA methylation in norepinephrine-induced heart hypertrophy and …